Cisplatin CAS: 15663-27-1
MF: Cl2H6N2Pt
Cisplatin is an apoptosis inducer and caspase-3 activator.

Cisplatin (CAS 15663-27-1)

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Sinónimo: CDDP; cis-Diammineplatinum(II) dichloride
Solicitud: Cisplatin is an apoptosis inducer and caspase-3 activator
Número de CAS: 15663-27-1
Pureza: ≥99%
Peso Molecular: 300.05
Fórmula Molecular: Cl2H6N2Pt
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Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


References

1. Bagasra, O., et al. 1985. Cancer Immunol. Immunother. 19: 142-147. PMID: 3157438
2. Bose, R.N. 2002. Mini Rev Med Chem. 2: 103-111. PMID: 12370072
3. Siddik, Z.H. 2003. Oncogene. 22: 7265-7279. PMID: 14576837
4. van Waardenburg, R.C., et al. 2004. J. Biol. Chem. 279: 54502-54509. PMID: 15471886

Apariencia :
Powder or crystalline
Estado de Materia :
Solid
Solubilidad :
Soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
ALMACENAMIENTO :
Store at room temperature
Punto de Fusión :
270° C
Densidad :
3.74 g/cm3
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
TP2450000
PubChem CID :
441203
Indice de Merck :
14: 2317
Número MDL :
MFCD00011623
Número EC :
239-733-8
SMILES :
N.N.Cl[Pt+2]Cl

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Cisplatin  Menciones del Producto

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Citaciones 1 a 10 de un total de 43

PMID: # 31374291  Li, X.|He, S.|Tian, Y.|Weiss, RM.|Martin, DT.| et al. 2019. Cell. Signal. 63: 109381.

PMID: # 29620162  Yang, X. et al. 2018. Int. J. Oncol. 52: 2021-2030.

PMID: # 29106395  2018. Lab. Invest. 98: 63-78.

PMID: # 28265008  Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 28692634  Westhoff, GL.|Chen, Y.|Teng, NNH.| et al. 2017. Int. J. Gynecol. Cancer. 27: 1602-1609.

PMID: # 29267289  Chen, Y. et al. 2017. PLoS ONE. 12: e0187222.

PMID: # 29132253  İnci, D. et al. 2017. J. Biomol. Struct. Dyn. 1-24.

PMID: # 28567715  Zhao, H. et al. 2017. Cell Oncol (Dordr). 40: 357-365.

PMID: # 28602975  Kollareddy, M.|Sherrard, A.|Park, JH.|Szemes, M.|Gallacher, K.|Melegh, Z.|Oltean, S.|Michaelis, M.|Cinatl, J.|Kaidi, A.|Malik, K.| et al. 2017. Cancer Lett. 403: 74-85.

PMID: # 28339648  Pendergraft, SS. et al. 2017. Biol. Reprod. 96: 720-732.

Citaciones 1 a 10 de un total de 43
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