HEATR7B1 Activators
Chemical activators of HEATR7B1 employ various cellular mechanisms to induce its activation. Forskolin is known for its ability to directly stimulate adenylyl cyclase, which leads to an increased production of cyclic AMP (cAMP) within the cell. The elevated levels of cAMP can then activate protein kinase A (PKA), a key signaling molecule that phosphorylates target proteins, including HEATR7B1. This phosphorylation is a post-translational modification that changes the function of HEATR7B1, leading to its activation. Similarly, 8-Br-cAMP and Dibutyryl-cAMP are analogs of cAMP that diffuse into cells and act as direct activators of PKA, bypassing the need for adenylyl cyclase activation. Once inside the cell, they bind to and activate PKA, which subsequently phosphorylates and activates HEATR7B1.
Other activators, such as PMA, act on different signaling pathways to achieve the same end. PMA activates protein kinase C (PKC), which then phosphorylates a plethora of cellular proteins, including HEATR7B1. Ionomycin and A23187 serve as calcium ionophores, raising the intracellular concentration of calcium ions, thereby activating calcium-dependent protein kinases that can phosphorylate HEATR7B1. Thapsigargin operates by disrupting calcium homeostasis via inhibition of the SERCA pump, leading to an increase in intracellular calcium levels that activate calcium-dependent protein kinases, potentially resulting in the phosphorylation and subsequent activation of HEATR7B1. Calyculin A and Okadaic Acid both act as protein phosphatase inhibitors, preventing the dephosphorylation of proteins within the cell. This inhibition supports a state of increased phosphorylation, thereby maintaining HEATR7B1 in an active form. Lastly, Anisomycin activates stress-activated protein kinases, which can target and phosphorylate HEATR7B1, while Aluminum Fluoride mimics the phosphate group and can activate G-proteins and downstream kinases that phosphorylate and activate HEATR7B1. Each of these chemicals, through their unique interactions with cellular enzymes and signaling pathways, brings about the phosphorylation and activation of HEATR7B1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate and thus activate HEATR7B1 directly. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentration, activating calcium-dependent protein kinases such as CaMK, which are known to phosphorylate and activate certain proteins, potentially including HEATR7B1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the SERCA pump leading to increased cytosolic calcium levels, which activates calcium-dependent kinases that can result in the phosphorylation and activation of HEATR7B1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins in the cell, which could include HEATR7B1, thereby maintaining it in an activated state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid, a protein phosphatase inhibitor, can enhance the phosphorylation status of proteins by preventing dephosphorylation, potentially keeping HEATR7B1 in an active phosphorylated state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is an activator of stress-activated protein kinases (SAPKs), which can phosphorylate and activate proteins involved in cellular stress responses, potentially including the activation of HEATR7B1. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
Aluminum Fluoride can mimic the phosphate group and activate G-proteins, which then may activate downstream kinases that phosphorylate and activate HEATR7B1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as an ionophore that increases intracellular calcium, which can activate calcium-dependent protein kinases that potentially phosphorylate and activate HEATR7B1. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cAMP analog that activates PKA by bypassing adenylyl cyclase, leading to the phosphorylation and activation of proteins such as HEATR7B1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is another cAMP analog that diffuses into cells and activates PKA, which then may phosphorylate and activate HEATR7B1. | ||||||