HEATR6 Inhibitors
HEATR6 inhibitors compounds that affect microtubule dynamics are prominent, including Paclitaxel, Nocodazole, Monastrol, Griseofulvin, and Colchicine. These substances target the polymerization and depolymerization of tubulin, a key component of microtubules, thereby potentially disrupting HEATR6-related activities if HEATR6 is involved in cellular transport or mitosis. Kinase inhibitors in this class, such as Alsterpaullone, Roscovitine, BI 2536, and MLN8237 (Alisertib), exert their effects by modulating the cell cycle checkpoints and mitotic spindle assembly. This modulation can impact HEATR6 if it has a role in chromosomal dynamics or cell division.
Brefeldin A, an inhibitor of vesicle trafficking between the endoplasmic reticulum and Golgi apparatus, could affect HEATR6's localization and function by altering its intracellular trafficking. Wortmannin, a phosphoinositide 3-kinase inhibitor, impacts signaling pathways that, if related to HEATR6, can modulate its cellular role. ZM447439, similar to Alisertib, targets Aurora kinases and can disrupt mitotic events such as chromosome alignment and segregation, processes in which HEATR6 might be implicated.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and can inhibit intracellular transport mechanisms potentially involving HEATR6. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules, possibly disrupting transport processes and mitotic functions where HEATR6 could play a role. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits the mitotic kinesin Eg5, which could alter microtubule dynamics affecting HEATR6-related transport activities. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule function, potentially altering the cellular localization and function of HEATR6. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds tubulin, leading to microtubule depolymerization, which could impact HEATR6 activity if it's involved in microtubule-dependent processes. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Inhibits cyclin-dependent kinases, potentially affecting cell cycle progression and HEATR6 function during mitosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Plk1 inhibitor that could disrupt spindle formation and chromosome segregation, processes where HEATR6 could be implicated. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Inhibits cyclin-dependent kinases and could influence cell cycle regulation and HEATR6-associated processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts protein transport by inhibiting the exchange of protein and other molecules between the endoplasmic reticulum and Golgi apparatus, potentially affecting HEATR6 localization and function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits phosphoinositide 3-kinases, which could affect signaling pathways and cellular processes involving HEATR6. | ||||||