HCFC1R1 Activators
HCFC1R1 Activators are a unique class of compounds that function by influencing the phosphorylation state and functional activity of HCFC1R1, a co-regulator in transcriptional processes. The compounds Forskolin, IBMX, EGF, PMA, Anisomycin, LY294002, Calyculin A, A23187, Phosphatidic acid, U0126, Okadaic acid, and S1P all interact with various signaling pathways that can enhance the functional activity of HCFC1R1. Forskolin and IBMX, for instance, are known to function by increasing cAMP levels, which in turn activate the PKA pathway, leading to the phosphorylation and activation of HCFC1R1. Similarly, EGF, Anisomycin, and Phosphatidic acid are potent activatorsof the EGFR, p38 MAPK, and mTOR pathways respectively, all of which can lead to the phosphorylation and activation of HCFC1R1. LY294002 and U0126, on the other hand, inhibit the PI3K-Akt and MEK1/2 pathways respectively, which can indirectly enhance the activity of the PKA pathway and subsequently HCFC1R1.
PMA is a potent activator of Protein Kinase C (PKC), another kinase known to phosphorylate and activate HCFC1R1. Calyculin A and Okadaic acid are inhibitors of protein phosphatases 1 (PP1) and 2A (PP2A), and their inhibition can prevent the dephosphorylation of HCFC1R1, maintaining its activated state. A23187 increases intracellular calcium levels that can activate the Calcineurin pathway. Activation of this pathway can lead to the dephosphorylation and activation of NFAT, which may interact with HCFC1R1 to enhance its function. Finally, S1P activates the S1P receptor, leading to the activation of the PI3K-Akt pathway which can phosphorylate and activate HCFC1R1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, which leads to an increase in cyclic AMP (cAMP) levels. Elevated cAMP levels can trigger the Protein Kinase A (PKA) pathway, that can phosphorylate and activate HCFC1R1, enhancing its function in transcriptional regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that prevents the breakdown of cAMP, leading to its accumulation. The increased cAMP can activate the PKA pathway, thereby enhancing the functional activity of HCFC1R1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can phosphorylate and activate HCFC1R1, thereby enhancing its function in transcriptional regulation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the p38 MAPK pathway. Activation of this pathway can lead to the phosphorylation and activation of HCFC1R1, enhancing its role in transcriptional regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K. Inhibition of PI3K can lead to reduced Akt phosphorylation, subsequently increasing the activity of the PKA pathway, which can enhance the functional activity of HCFC1R1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). The inhibition of these phosphatases can prevent the dephosphorylation of HCFC1R1, maintaining its activated state and enhancing its function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can activate the Calcineurin pathway. Activation of this pathway can lead to the dephosphorylation and activation of NFAT, which may interact with HCFC1R1 to enhance its function in transcriptional regulation. | ||||||
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $104.00 $239.00 $409.00 | ||
Phosphatidic acid is a lipid second messenger that activates the mTOR pathway. Activation of mTOR can lead to the phosphorylation and activation of HCFC1R1, enhancing its function in transcription regulation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Inhibition of these phosphatases can prevent the dephosphorylation of HCFC1R1, maintaining its activated state and enhancing its function. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates the S1P receptor, leading to the activation of the PI3K-Akt pathway. Activation of this pathway can lead to the phosphorylation and activation of HCFC1R1, enhancing its function in transcriptional regulation. | ||||||