HAS3 Inhibitors
HAS3 inhibitors, short for Hyaluronan Synthase 3 inhibitors, belong to a class of chemical compounds that specifically target the enzyme Hyaluronan Synthase 3 (HAS3). HAS3 is a critical enzyme involved in the biosynthesis of hyaluronan (HA), a large and naturally occurring polysaccharide found in various tissues and fluids within the human body. HA plays a crucial role in maintaining tissue hydration, lubrication, and elasticity, and it is implicated in various physiological and pathological processes, including tissue development, inflammation, wound healing, and cancer progression. Inhibition of HAS3 can modulate the production of HA, which, in turn, can have a significant impact on these biological processes.
HAS3 inhibitors work by interfering with the enzymatic activity of HAS3, thereby reducing the synthesis of HA molecules. These inhibitors can act through various mechanisms, such as competitive binding to the HAS3 enzyme's active site or disrupting the enzyme's structural integrity. By regulating HA production, HAS3 inhibitors have the ability to influence cell behavior, tissue integrity, and the microenvironment within various physiological contexts. Understanding the properties and mechanisms of HAS3 inhibitors is essential for researchers seeking to develop novel strategies for modulating HA levels in different tissues, opening doors to a wide range of applications.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-MU inhibits HAS3 by depleting the substrate UDP-glucuronic acid, thus limiting HA synthesis. | ||||||
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $201.00 $779.00 | ||
Glucosamine may alter glycosylation processes, potentially affecting HAS3's enzymatic function. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
This compound inhibits inosine monophosphate dehydrogenase, leading to reduced nucleotide synthesis and potentially downregulating HAS3 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to affect several signaling pathways and may reduce HAS3 expression indirectly. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Known for its effects on lysosomal activity, it may alter glycosylation and HA synthesis, affecting HAS3 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As a tyrosine kinase inhibitor, genistein may impact HAS3 by interfering with intracellular signaling required for its expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects various signaling pathways and may downregulate HAS3 expression as part of its broad biological effects. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
CAPE is known to affect NF-κB pathway, which can be involved in the regulation of HAS3 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can act as a cofactor for enzymes, and varying its levels can influence various metabolic pathways, potentially including HAS3 synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences a number of signaling pathways and may have an inhibitory effect on HAS3 expression. | ||||||