H2-M10.4 inhibitors belong to a specific category of chemical compounds designed to modulate the activity of the H2-M10.4 protein. H2-M10.4, also known as histocompatibility 2, M region locus 10.4, is a protein that is part of the major histocompatibility complex (MHC) system in mice. The MHC plays a critical role in the immune response by presenting antigenic peptides to T cells, allowing the immune system to recognize and respond to foreign pathogens. H2-M10.4, similar to other MHC molecules, is involved in the intricate process of antigen presentation, a fundamental mechanism that enables the body to initiate immune responses against infections. The development of H2-M10.4 inhibitors is motivated by the primary goal of selectively interacting with the H2-M10.4 protein, potentially influencing its antigen-presenting activity and impacting immune recognition processes.
Typically, H2-M10.4 inhibitors consist of small molecules or chemical compounds specifically designed to bind to H2-M10.4, targeting either its active site or allosteric sites. This interaction can lead to the modulation of H2-M10.4's behavior, potentially affecting its ability to present antigenic peptides to T cells and, consequently, influencing the immune response against foreign antigens. Researchers are primarily dedicated to unraveling the molecular mechanisms and functions of H2-M10.4 within the MHC system and how inhibiting its activity with these compounds may provide insights into the intricate immune recognition processes. The development of H2-M10.4 inhibitors represents an active area of research within the fields of immunology and molecular pharmacology, contributing to a deeper understanding of the immune system's functioning and its role in detecting and responding to foreign antigens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog of cytidine that can be incorporated into DNA and RNA, potentially disrupting DNA methylation and thus gene expression patterns. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to intercalate into DNA, which may disrupt DNA replication and RNA synthesis, possibly leading to reduced gene expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
A topoisomerase I inhibitor that prevents DNA relaxation, which is necessary for transcription, potentially reducing gene expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
A uracil analog that interferes with nucleotide synthesis and can be incorporated into RNA, potentially disrupting gene expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Inhibits topoisomerase II, leading to DNA strand breaks and potentially affecting transcription processes, reducing gene expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II, potentially leading to a decrease in mRNA synthesis and gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
A potent inhibitor of RNA polymerase II, leading to a direct decrease in mRNA synthesis and gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Known to inhibit the transcription of various genes, potentially affecting gene expression through multiple pathways. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Can inhibit protein synthesis by preventing the initial elongation step of translation, indirectly affecting gene expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Binds to Hsp90 and inhibits its function, which might indirectly reduce the stability and function of several client proteins that regulate gene expression. | ||||||