GTPBP10 Activators
GTPBP10 Activators encompass various chemical compounds that play roles in enhancing the functional activity of GTPBP10, a protein implicated in ribosome biogenesis and RNA processing. Forskolin and Rolipram, by increasing intracellular cAMP levels through different mechanisms, both lead to the activation of protein kinase A (PKA). PKA, in turn, phosphorylates different substrates that may affect ribosome assembly, thereby potentially enhancing the function of GTPBP10 in this process. Similarly, Epigallocatechin gallate (EGCG) inhibits various kinases, which may reduce competitive signaling and indirectly lead to an upregulation of pathways that promote the activity of GTPBP10 in ribosomal RNA processing. Sphingosine-1-phosphate (S1P) and LY294002 modulate the PI3K/AKT pathway, with S1P activating and LY294002 inhibiting it. This modulation influences translation initiation, aprocess that GTPBP10 is involved in, and could result in its enhanced activity within ribosomes. Ionomycin, by raising intracellular calcium levels, activates calcium-dependent kinases that may subsequently impact GTPBP10's role in ribosome assembly.
The second paragraph of GTPBP10 Activators' description continues with the chemical PMA, which activates protein kinase C (PKC), potentially leading to enhanced GTPBP10 activity by influencing substrates in ribosome biogenesis. The cAMP analog 8-Bromo-cAMP also targets PKA, further emphasizing the role of PKA-mediated phosphorylation in promoting GTPBP10's function. Okadaic acid, by inhibiting protein phosphatases, maintains phosphorylation states that could stabilize complexes in which GTPBP10 operates, thus indirectly enhancing its activity. The MEK inhibitor U0126 and the p38 MAPK inhibitor SB203580 may drive cell signaling towards enhancing ribosome assembly and function, processes where GTPBP10 is integral, by altering signaling dynamics. Finally, Anisomycin, although primarily known as a protein synthesis inhibitor, can activate stress-activated protein kinases leading to upregulation of components involved in ribosome biogenesis, potentially benefiting GTPBP10's functional role in this essential cellular process. Together, these compounds act through various biochemical mechanisms to foster the enhancement of GTPBP10's activity in ribosome assembly and maintenance without the need for direct activation or upregulation of its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP levels can enhance GTPBP10 activity by PKA-dependent phosphorylation of proteins involved in ribosome assembly, where GTPBP10 functions. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterases, particularly PDE4, which prevents the breakdown of cAMP. The resultant increase in cAMP levels can indirectly enhance GTPBP10's function in ribosome biogenesis through PKA-mediated signaling events. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits multiple kinases. By inhibiting competitive pathways, it may indirectly upregulate signaling pathways that enhance GTPBP10’s role in ribosomal RNA processing and ribosome assembly, due to decreased regulatory interference. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P acts through G protein-coupled receptors to activate multiple signaling pathways, including PI3K/AKT. PI3K/AKT pathway activation can lead to enhanced translation initiation, which may indirectly increase GTPBP10 activity in ribosomes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase, which may indirectly influence GTPBP10's role in ribosome assembly through downstream effects. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate signaling pathways. By inhibiting PI3K, it may indirectly enhance GTPBP10 activity by reducing negative regulation on the ribosome assembly process in which GTPBP10 is involved. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can shift signaling pathways towards those that enhance ribosome assembly and function. As GTPBP10 is involved in these processes, it may indirectly benefit from the altered signaling dynamics. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate substrates involved in ribosome biogenesis. This activation may lead to enhanced activity of GTPBP10 through PKC-mediated signaling pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that can activate PKA. PKA activation can lead to phosphorylation events that indirectly enhance GTPBP10's function in ribosome assembly and maintenance. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels. This may indirectly enhance GTPBP10 activity by stabilizing protein complexes involved in ribosome biogenesis. | ||||||