GTL3 Activators
GTL3 activators primarily operate by modulating cellular processes tied to ciliary structure and function, given GTL3's association with these cellular appendages. For instance, Forskolin and IBMX, by elevating cAMP levels, can impact ciliary beating and thereby, possibly induce GTL3's function in this context. The modulation of cilia length by chemicals like Retinoic Acid and LY-294002 underscores the intricate balance of proteins, like GTL3, required for maintaining optimal ciliary function.
Similarly, the influence of Spermine on cell growth and cilia length might demand a recalibration of ciliary proteins, potentially involving GTL3. Agents like Rapamycin, which inhibit the mTOR pathway, have broad cellular effects, and their impact on cilia may indirectly necessitate GTL3's function. Lithium and Chloral hydrate, through their influence on ciliogenesis and cilia length, respectively, could indirectly engage GTL3 in ciliary maintenance or repair processes. Lastly, chemicals that target foundational ciliary components, like Nocodazole with microtubules and Cytochalasin D with actin filaments, may indirectly call upon GTL3's role in ensuring the structural and functional integrity of cilia.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By stimulating adenylate cyclase, Forskolin increases cAMP levels. Elevated cAMP can indirectly activate GTL3 by modulating ciliary beating which GTL3 is associated with. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits phosphodiesterase, thereby increasing cAMP levels. Elevated cAMP may indirectly stimulate GTL3 due to its role in ciliary function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid modulates cilia length. Changes in cilia length and dynamics can necessitate the activation or modulation of associated proteins like GTL3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
By inhibiting PI3K, LY-294002 affects ciliary length. This alteration in ciliary structure can indirectly necessitate the role or activation of GTL3. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine's involvement in cell growth and its influence on primary cilia length may necessitate the activation or modulation of proteins like GTL3 linked to ciliary structures. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
By inhibiting mTOR, a pathway that affects cilia function, Rapamycin might necessitate the activation or modulation of GTL3 associated with ciliary dynamics. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can induce ciliogenesis. By promoting the formation and function of cilia, it may indirectly stimulate the activities of associated proteins like GTL3. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
By increasing intracellular calcium levels, Ionomycin affects ciliary beating. This can indirectly activate GTL3 due to its association with ciliary dynamics. | ||||||