GS28 Inhibitors
GS28 inhibitors belong to a specific chemical class known for their ability to modulate cellular processes by targeting the GS28 protein. GS28, a Golgi snare protein, plays a crucial role in intracellular membrane trafficking and vesicular transport within eukaryotic cells. The GS28 inhibitors are designed to disrupt the normal functioning of GS28, thereby impeding the fusion of transport vesicles with their target membranes in the Golgi apparatus. This inhibition results in alterations to the secretory pathway, affecting the sorting and processing of proteins that transit through the Golgi complex.
GS28 inhibitors typically possess specific binding motifs that interact with key residues of the GS28 protein. This interaction may involve hydrogen bonding, hydrophobic interactions, or electrostatic forces, leading to a conformational change in GS28 that interferes with its role in vesicular transport. By selectively targeting GS28, these inhibitors provide researchers with a valuable tool to investigate the intricacies of intracellular trafficking mechanisms. Understanding the impact of GS28 inhibition on cellular processes contributes to the broader comprehension of membrane dynamics and the regulation of protein trafficking.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A can disrupt the structure of the Golgi apparatus, indirectly affecting GS28 function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin can alter Golgi function by affecting ion balances, impacting vesicle trafficking and GS28. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole can depolymerize microtubules, affecting vesicular transport and thus GS28. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
By depolymerizing microtubules, Colchicine can alter vesicle transport, affecting GS28. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore can inhibit dynamin, a key protein in vesicle formation, subsequently impacting GS28. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
This compound can disrupt actin filaments, which are involved in vesicle movement, affecting GS28. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D can inhibit actin polymerization, affecting vesicle transport and GS28. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide can stabilize actin filaments, affecting vesicle movement and GS28. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin can inhibit PI3K, a protein involved in vesicle formation, impacting GS28. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 can inhibit PI3K, similar to Wortmannin, affecting vesicle formation and GS28. | ||||||