GS28 Activators
GS28, also known as GOSR1 (Golgi SNAP Receptor Complex Member 1), is a membrane traffic protein that is involved in vesicular transport between the endoplasmic reticulum and the Golgi apparatus. As a SNAP receptor (SNARE), it plays a critical role in the docking and fusion of vesicles by forming a SNARE complex with other membrane-associated proteins. GS28 activators, if they were to be characterized, would likely encompass a range of molecules designed to modulate the activity of GS28, enhancing its role in vesicular trafficking.
Direct GS28 activators would be molecules that bind to GS28 and induce a conformational change that promotes its interaction with target SNARE proteins, thus facilitating vesicle docking and fusion. These activators might enhance the stability of the SNARE complex or increase the affinity of GS28 for its binding partners. By doing so, they would effectively amplify the protein's inherent function in vesicle transport, which is a crucial step in the secretory pathway of cells. Indirect activators would operate by modulating the expression levels of GS28, altering its localization, or affecting its post-translational modifications, which can be essential for its function. For example, a compound that increases the transcription of the GS28 gene would result in an augmented production of the protein, potentially leading to a more efficient vesicle trafficking process. Other indirect activators might protect GS28 from degradation or assist in its proper folding and assembly into functional SNARE complexes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a potent activator of Protein Kinase C (PKC), which is involved in multiple cell signaling pathways. GS28, a SNARE protein, is involved in vesicular transport and its function can be influenced by PKC activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP). cAMP is a secondary messenger involved in various signaling pathways that could influence the vesicular transport processes that GS28 is part of. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a regulator of cell growth and proliferation. This can indirectly influence GS28 as it affects the protein processing and trafficking pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of proteins in the cell. This can affect GS28's role in protein trafficking. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK3, potentially influencing the phosphorylation status of proteins. This might indirectly modulate GS28 function in vesicle trafficking. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that can increase gene transcription, potentially influencing GS28 expression. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a CDK inhibitor that can impact the cell cycle, potentially affecting GS28's role in protein trafficking during different phases of the cell cycle. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a HDAC inhibitor that can increase gene transcription, potentially affecting GS28 expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, which can indirectly influence GS28 function because vesicular transport relies on the microtubule network. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can prevent DNA methylation and promote gene expression. This can potentially lead to increased expression of GS28. | ||||||