GRINA Activators
GRINA Activators as a chemical class includes a range of compounds that interact with the NMDA receptor complex, where GRINA is a subunit. These chemicals either serve as co-agonists, enhance synaptic activity, or modulate neurotransmitter levels. For instance, glycine and D-serine are known co-agonists that are necessary for NMDA receptor activation, where GRINA can be involved. Sarcosine, by inhibiting glycine transporters, indirectly increases the levels of glycine available for receptor activation. Similarly, caffeine, through its stimulatory effect on neuronal activity, may result in increased expression or function of GRINA.
Compounds like huperzine A directly enhance NMDA receptor function and may increase the activity of GRINA-containing receptors. Tianeptine, through its effects on glutamatergic transmission, could modify GRINA function within the receptor complex. Minerals like magnesium and zinc, despite their classical role as NMDA receptor blockers, are known to have nuanced effects on receptor activation at physiological concentrations, potentially affecting GRINA's role in the NMDA receptor complex. L-Theanine, while less direct, has been associated with modulation of neurotransmission that could impact GRINA function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
As a co-agonist of NMDA receptors, glycine binding is required for receptor activation and may enhance the function of GRINA-containing receptors. | ||||||
D-Serine | 312-84-5 | sc-391671 sc-391671A sc-391671B | 5 g 25 g 100 g | $43.00 $128.00 $204.00 | ||
Another co-agonist of NMDA receptors, it can enhance receptor function and potentially increase the activity of GRINA-associated complexes. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Can enhance neuronal activity, which may indirectly lead to the upregulation of GRINA through increased synaptic activity. | ||||||
IGF-1R Inhibitor, PPP | 477-47-4 | sc-204008A sc-204008 sc-204008B | 1 mg 10 mg 100 mg | $138.00 $203.00 $895.00 | 63 | |
Although a biological material, its mimetic chemicals can enhance synaptic plasticity and may upregulate NMDA receptor function, potentially affecting GRINA. | ||||||
(−)-Huperzine A | 102518-79-6 | sc-200183 sc-200183A | 1 mg 5 mg | $143.00 $362.00 | 1 | |
An NMDA receptor enhancer, it may increase the activity of NMDA receptors including those containing GRINA subunits. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Similar to magnesium, zinc can modulate NMDA receptor activity and thus indirectly affect GRINA function within the receptor complex. | ||||||
L-Theanine | 3081-61-6 | sc-204787 sc-204787A | 1 g 5 g | $58.00 $142.00 | 1 | |
Known to modulate neurotransmitter release and may influence NMDA receptor activity, thus potentially affecting GRINA. | ||||||
Tianeptine | 66981-73-5 | sc-213044 sc-213044A | 10 mg 50 mg | $250.00 $422.00 | ||
Has been found to modulate glutamatergic neurotransmission, which could affect GRINA functionality within the NMDA receptor complex. | ||||||