GREB1L Inhibitors
GREB1L inhibitors are a class of chemical compounds that target the gene product of *GREB1L*, a gene known to be involved in various biological processes, particularly in gene regulation. GREB1L, or Growth Regulation by Estrogen in Breast Cancer 1 Like, is a coactivator protein that plays a role in hormone-mediated transcription. Compounds that inhibit the function of GREB1L are typically designed to disrupt its regulatory activity within the cellular environment. These inhibitors can modulate downstream effects on transcription factors and other proteins that interact with GREB1L, affecting cellular signaling pathways. By inhibiting GREB1L's action, these molecules can alter gene expression patterns, potentially impacting processes like cell differentiation and growth regulation.
The chemical structure of GREB1L inhibitors often features specific functional groups that enable them to bind selectively to their target, hindering GREB1L's ability to facilitate transcriptional coactivation. These inhibitors are typically studied for their capacity to modulate nuclear receptor signaling, particularly in contexts where GREB1L is known to have a regulatory role. Structurally, they may incorporate features such as hydrophobic moieties or hydrogen bond acceptors that enhance their affinity for GREB1L or its interacting partners. GREB1L inhibitors are of interest in various research contexts due to their potential to shed light on fundamental molecular pathways governed by this gene, particularly those related to transcriptional regulation and its downstream effects on cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid (ATRA) can inhibit GREB1 like retinoic acid receptor coactivator by competitively binding to the retinoic acid receptors, preventing the coactivator from interacting with the receptor and thus inhibiting its function in gene transcription regulation. | ||||||
LG 100268 | 153559-76-3 | sc-211737 | 5 mg | $390.00 | 2 | |
LG100268 is a retinoid X receptor (RXR) selective ligand that can inhibit GREB1 like retinoic acid receptor coactivator by promoting the formation of RXR homodimers, which may reduce the availability of RXR to form heterodimers with RAR that the coactivator would bind to. | ||||||
BMS 493 | 215030-90-3 | sc-361124 sc-361124A | 10 mg 50 mg | $459.00 $1428.00 | 7 | |
BMS493 is a pan-RAR inverse agonist that can inhibit GREB1 like retinoic acid receptor coactivator by binding to retinoic acid receptors and causing conformational changes that prevent coactivator recruitment, thereby inhibiting its function in transcription. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Targretin (Bexarotene) is a retinoid X receptor (RXR) agonist that can inhibit GREB1 like retinoic acid receptor coactivator by altering RXR-targeted gene expression in a way that may counteract the effects or demand for coactivator interaction with RXR. | ||||||
Adapalene | 106685-40-9 | sc-203803 sc-203803A | 10 mg 50 mg | $66.00 $332.00 | 2 | |
Adapalene, a synthetic retinoid, can inhibit GREB1 like retinoic acid receptor coactivator by selectively binding to RAR beta and gamma, possibly altering the transcription regulation in which the coactivator is involved, without directly binding to it. | ||||||
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
Tamibarotene is a synthetic retinoid that can inhibit GREB1 like retinoic acid receptor coactivator by preferentially binding to RAR alpha and beta, potentially changing the transcription dynamics and reducing the coactivator's functional interaction with RARs. | ||||||
AM 580 | 102121-60-8 | sc-203505 sc-203505A | 5 mg 25 mg | $99.00 $390.00 | 2 | |
Am580 is a synthetic retinoid that can inhibit GREB1 like retinoic acid receptor coactivator by acting as an RAR alpha agonist, which might change the transcriptional regulation and reduce the interaction of the coactivator with RAR alpha. | ||||||
TTNPB | 71441-28-6 | sc-203303 sc-203303A sc-203303B | 10 mg 25 mg 50 mg | $210.00 $347.00 $640.00 | 20 | |
TTNPB (Arotinoid acid) can inhibit GREB1 like retinoic acid receptor coactivator by functioning as an RAR agonist, which can lead to a transcriptional response that reduces the necessity for coactivator association with RARs. | ||||||
SR 11237 | 146670-40-8 | sc-296418 sc-296418A | 5 mg 50 mg | $211.00 $877.00 | ||
SR11237 is a synthetic retinoid that can inhibit GREB1 like retinoic acid receptor coactivator by acting as an RXR antagonist, potentially changing the expression of RXR-targeted genes and thus affecting the coactivator's functional contributions. | ||||||
MM 11253 | 345952-44-5 | sc-361255 sc-361255A | 10 mg 50 mg | $477.00 $2040.00 | 2 | |
SR11253 is a synthetic retinoid that can inhibit GREB1 like retinoic acid receptor coactivator by antagonizing RXRs, which may lead to a change in gene expression that reduces the interaction of the coactivator with these receptors. | ||||||