Molecular structure of SR 11237, CAS Number: 146670-40-8
SR 11237 (CAS 146670-40-8)
Alternate Names:
BMS 649
Application:
SR 11237 is A pan RXR agonist with without RAR activity
CAS Number:
146670-40-8
Purity:
≥98%
Molecular Weight:
380.48
Molecular Formula:
C24H28O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SR 11237 is primarily utilized in biochemical and pharmacological research, focusing on its interactions with nuclear receptors. This compound is of particular interest for its ability to act as a selective agonist or modulator of specific receptors, which are in regulating gene expression and cellular functions. Researchers use SR 11237 to study its effects on transcriptional activities, exploring its potential role in influencing metabolic pathways and cellular development. Additionally, SR 11237 is employed in studies looking at receptor binding affinity and specificity, contributing to a deeper understanding of receptor-ligand interactions and signaling mechanisms.
SR 11237 (CAS 146670-40-8) References
- Lineage-specific modulation of calcium pump expression during myeloid differentiation. | Launay, S., et al. 1999. Blood. 93: 4395-405. PMID: 10361138
- Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells. | Ivanova, D., et al. 2004. Bioorg Med Chem Lett. 14: 4257-61. PMID: 15261282
- Retinoic acid mediates the expression of glutamate transporter-1 in rat astrocytes through genomic RXR action and non-genomic protein kinase C signaling pathway. | Chan, TJ., et al. 2012. J Neurochem. 121: 537-50. PMID: 22380620
- Divergent teratogenicity of agonists of retinoid X receptors in embryos of zebrafish (Danio rerio). | Shi, H., et al. 2012. Ecotoxicology. 21: 1465-75. PMID: 22526925
- Correction of all-trans retinoic acid deficiency in alcoholic cirrhosis lessens the excessive inflammatory monocyte response: a translational study. | Ouziel, R., et al. 2014. Liver Int. 34: 343-52. PMID: 23834309
- The Retinoid Agonist Tazarotene Promotes Angiogenesis and Wound Healing. | Al Haj Zen, A., et al. 2016. Mol Ther. 24: 1745-1759. PMID: 27480772
- Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model. | Dupuis, H., et al. 2019. Int J Mol Sci. 20: PMID: 31635173
- A pleiotropic response is induced in F9 embryonal carcinoma cells and rhino mouse skin by All-trans-retinoic acid, a RAR agonist but not by SR11237, a RXR-selective agonist. | Gendimenico, GJ., et al. 1994. J Invest Dermatol. 102: 676-80. PMID: 8176247
- Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. | Minucci, S., et al. 1996. Proc Natl Acad Sci U S A. 93: 1803-7. PMID: 8700839
- Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. | Beard, RL., et al. 1996. J Med Chem. 39: 3556-63. PMID: 8784454
- Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. | Chiba, H., et al. 1997. Mol Cell Biol. 17: 3013-20. PMID: 9154799
- Retinoid antagonism of NF-IL6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma. | Nagpal, S., et al. 1997. Mol Cell Biol. 17: 4159-68. PMID: 9199351
- Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. | Nagpal, S., et al. 1997. J Invest Dermatol. 109: 91-5. PMID: 9204961
- Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation. | Thacher, SM., et al. 1997. J Pharmacol Exp Ther. 282: 528-34. PMID: 9262312
- Requirements for repression of retinoid X receptor by the oncoprotein P75gag-v-erbA and the thyroid hormone receptors. | Wahlström, GM. and Vennström, B. 1998. Mol Endocrinol. 12: 645-53. PMID: 9605927
Inhibitor of:
GREB1L, RARα2, Rev-erbβ, RXRβ, RXRβ2, and TIG2.Activator of:
RAR gamma, RORβ, RXR, RXR alpha, and RXR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR 11237, 5 mg | sc-296418 | 5 mg | $211.00 | |||
| US: Only available in the US | ||||||
SR 11237, 50 mg | sc-296418A | 50 mg | $877.00 | |||
| US: Only available in the US | ||||||