Molecular structure of MM 11253, CAS Number: 345952-44-5
MM 11253 (CAS 345952-44-5)
See product citations (2)
Alternate Names:
6-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthoic acid
Application:
MM 11253 is a selective RARγ antagonist
CAS Number:
345952-44-5
Molecular Weight:
462.67
Molecular Formula:
C28H30O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MM 11253 is a selective RARgamma antagonist. MM11253 has also been shown to block the growth inhibitory ability of RARgamma-selective agonists in squamous cell carcinoma (SCC)-25 cells.MM-11253 is a synthetic retinoid with a unique conformation that functions as a selective antagonist for retinoic acid receptor γ (RARγ). It effectively counteracts the growth-inhibiting effects induced by RARγ-selective agonists, without affecting the activity of all-trans retinoic acid. This quality makes MM-11253 an antiapoptotic agent in squamous cell carcinoma (SCC)-25 cells, serving as a selective RARγ antagonist that impedes the growth inhibition triggered by RARγ-selective agonists.
MM 11253 (CAS 345952-44-5) References
- Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. | Le, Q., et al. 2000. Oncogene. 19: 1457-65. PMID: 10723137
- Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. | Holmes, WF., et al. 2000. J Cell Physiol. 185: 61-7. PMID: 10942519
- Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. | Uchibe, K., et al. 2017. J Orthop Res. 35: 1096-1105. PMID: 27325507
- Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease. | Habchi, J., et al. 2017. Proc Natl Acad Sci U S A. 114: E200-E208. PMID: 28011763
- Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish. | Chawla, B., et al. 2018. Invest Ophthalmol Vis Sci. 59: 1924-1935. PMID: 29677354
- All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. | Bi, W., et al. 2018. Cell Biosci. 8: 48. PMID: 30159139
- Radiation and host retinoic acid signaling promote the induction of gut-homing donor T cells after allogeneic hematopoietic stem cell transplantation. | Zheng, J., et al. 2020. Am J Transplant. 20: 64-74. PMID: 31207088
- All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro. | Sun, W., et al. 2020. FEBS Open Bio. 10: 396-406. PMID: 31957262
- The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation. | Wang, S., et al. 2020. Drug Des Devel Ther. 14: 297-308. PMID: 32158187
- Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells. | Ding, S., et al. 2020. Gastroenterology. 159: 214-226.e1. PMID: 32247021
- Retinoic acid receptor γ activation promotes differentiation of human induced pluripotent stem cells into esophageal epithelium. | Koterazawa, Y., et al. 2020. J Gastroenterol. 55: 763-774. PMID: 32556644
- Olfactory Receptor OR7A17 Expression Correlates with All-Trans Retinoic Acid (ATRA)-Induced Suppression of Proliferation in Human Keratinocyte Cells. | Kim, H., et al. 2021. Int J Mol Sci. 22: PMID: 34830183
- Synthetic Retinoid Kills Drug-Resistant Cancer Stem Cells via Inducing RARγ-Translocation-Mediated Tension Reduction and Chromatin Decondensation. | Zhang, Y., et al. 2022. Adv Sci (Weinh). 9: e2203173. PMID: 36031407
- Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase. | Yamakawa, K., et al. 2023. Cancer Cell Int. 23: 94. PMID: 37198667
Inhibitor of:
1300002K09Rik, GREB1L, RAR gamma, RXRβ, and RXRβ2.Activator of:
RAR beta, and RORβ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MM 11253, 10 mg | sc-361255 | 10 mg | $468.00 | |||
MM 11253, 50 mg | sc-361255A | 50 mg | $2000.00 |