Date published: 2025-10-22

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granzyme A Inhibitors

The class of Granzyme A Inhibitors comprises a diverse range of compounds primarily characterized by their ability to interfere with the proteolytic activity of Granzyme A. These inhibitors employ various mechanisms, such as directly binding to the active site of the enzyme (as in the case of AEBSF and Gabexate Mesylate), or indirectly affecting its function by modulating related proteases or signaling pathways (like Marimastat or E-64). Granzyme A plays a crucial role in immune response by inducing apoptosis in target cells. Inhibitors like Aprotinin and Leupeptin work by binding to the protease, hindering its interaction with substrates. Others, such as Pepstatin A and Z-VAD-FMK, are more indirect, targeting other enzymes in the apoptosis pathway, thus potentially modulating the overall effect of Granzyme A. The inhibitors TLCK and TPCK are more specific in their action, selectively targeting serine proteases with similar characteristics to Granzyme A.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

3,4 Dichloroisocoumarin

51050-59-0sc-3502
5 mg
$246.00
8
(1)

3,4-Dichloroisocoumarin is a distinctive compound known for its selective reactivity in biochemical pathways. Its structure allows for specific interactions with serine proteases, influencing enzymatic activity through competitive inhibition. The presence of chlorine substituents enhances its electrophilic character, facilitating nucleophilic attack and subsequent reaction kinetics. This compound's unique conformation also contributes to its ability to modulate protein interactions, impacting cellular processes.

AEBSF hydrochloride

30827-99-7sc-202041
sc-202041A
sc-202041B
sc-202041C
sc-202041D
sc-202041E
50 mg
100 mg
5 g
10 g
25 g
100 g
$50.00
$120.00
$420.00
$834.00
$1836.00
$4896.00
33
(1)

Serine protease inhibitor; could inhibit Granzyme A by binding to its active site.

Nafamostat mesylate

82956-11-4sc-201307
sc-201307A
10 mg
50 mg
$80.00
$300.00
4
(1)

Nafamostat mesylate is a synthetic compound characterized by its ability to interact with serine proteases, particularly granzyme A. Its unique structure enables it to form stable complexes with target enzymes, altering their activity through non-covalent interactions. The compound exhibits rapid reaction kinetics, allowing for efficient modulation of proteolytic pathways. Additionally, its specific molecular configuration enhances selectivity, influencing downstream signaling cascades in cellular environments.

Gabexate mesylate

56974-61-9sc-215066
5 mg
$100.00
(0)

Serine protease inhibitor; might block Granzyme A's active site, reducing its proteolytic activity.

Marimastat

154039-60-8sc-202223
sc-202223A
sc-202223B
sc-202223C
sc-202223E
5 mg
10 mg
25 mg
50 mg
400 mg
$165.00
$214.00
$396.00
$617.00
$4804.00
19
(1)

Broad-spectrum metalloproteinase inhibitor; could indirectly affect Granzyme A's activation or function.

E-64

66701-25-5sc-201276
sc-201276A
sc-201276B
5 mg
25 mg
250 mg
$275.00
$928.00
$1543.00
14
(0)

Irreversible cysteine protease inhibitor; might indirectly influence Granzyme A's activity.

Aprotinin

9087-70-1sc-3595
sc-3595A
sc-3595B
10 mg
100 mg
1 g
$110.00
$400.00
$1615.00
51
(2)

Kunitz-type serine protease inhibitor; could bind to Granzyme A, inhibiting its function.

Leupeptin hemisulfate

103476-89-7sc-295358
sc-295358A
sc-295358D
sc-295358E
sc-295358B
sc-295358C
5 mg
25 mg
50 mg
100 mg
500 mg
10 mg
$72.00
$145.00
$265.00
$489.00
$1399.00
$99.00
19
(3)

Inhibits serine and cysteine proteases; might reduce Granzyme A's proteolytic activity.

Z-VAD-FMK

187389-52-2sc-3067
500 µg
$74.00
256
(6)

Broad-spectrum caspase inhibitor; might indirectly inhibit pathways activated by Granzyme A.

L-Lysine

56-87-1sc-207804
sc-207804A
sc-207804B
25 g
100 g
1 kg
$93.00
$258.00
$519.00
(1)

Specific inhibitor of trypsin-like serine proteases; could inhibit Granzyme A activity.