GPx-1 Activators
Common GPx-1 Activators include, but are not limited to D,L-Sulforaphane CAS 4478-93-7, Curcumin CAS 458-37-7, Resveratrol CAS 501-36-0, Selenium CAS 7782-49-2 and (-)-Epigallocatechin Gallate CAS 989-51-5.
Glutathione peroxidase 1 (GPx-1) stands as a sentinel in the body's antioxidant defense system, playing a pivotal role in neutralizing harmful reactive oxygen species (ROS). As an enzyme primarily found in the cytosol of nearly all mammalian tissues, GPx-1 catalyzes the reduction of hydrogen peroxide, converting it to water. This reaction is facilitated by the presence of glutathione (GSH), which acts as a reducing agent, getting oxidized in the process to glutathione disulfide (GSSG). By performing this crucial function, GPx-1 helps maintain a balance between the production and removal of ROS, ensuring that cellular structures, including DNA, proteins, and lipids, are shielded from oxidative damage. The functionality and efficiency of GPx-1 are, therefore, integral to cellular health and the overarching stability of biological systems.
Activators of GPx-1 are specialized molecules or compounds designed to augment the expression or enzymatic activity of GPx-1. These activators may operate by enhancing the transcription or translation of the GPx-1 gene, stabilizing the enzyme's three-dimensional structure, or optimizing its substrate-binding affinity. The presence of GPx-1 activators can bolster the cellular capacity to quench ROS, reinforcing the antioxidant defenses and promoting cellular resilience against oxidative stress. Delving into the realm of GPx-1 activators provides a glimpse into the intricate world of redox biology and the molecular mechanisms that underpin cellular defense against oxidative insults. As the scientific community continues to probe the depths of cellular biochemistry, the role of GPx-1 and its activators stands out, offering a testament to the intricate balance of reactions that preserve cellular integrity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which can upregulate the expression of antioxidant enzymes, including GPx-1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can activate the Nrf2-antioxidant response element pathway, leading to increased GPx-1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has antioxidant properties and can upregulate GPx-1 expression as part of the cellular defense against oxidative stress. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
As an essential component of GPx enzymes, adequate selenium promotes GPx-1 activity and potentially its expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major polyphenol in green tea, can enhance GPx-1 expression via its antioxidant properties. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can stimulate the Nrf2 pathway, promoting the expression of antioxidant enzymes, including GPx-1. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid can upregulate the expression of GPx-1, enhancing the cellular defense against oxidative stress. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC can promote GPx-1 expression by providing cysteine, a precursor for glutathione synthesis, and by modulating redox status. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
tBHQ activates Nrf2, which in turn can induce the expression of antioxidant enzymes, including GPx-1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate GPx-1 expression as part of its role in differentiation and cellular defense mechanisms. | ||||||