GPSM3 Inhibitors
Chemical inhibitors of GPSM3 can influence the protein's regulatory role in various cellular signaling pathways by targeting the activity of enzymes and other proteins that GPSM3 interacts with or influences. Bisindolylmaleimide and Go 6983, both protein kinase C (PKC) inhibitors, can impede the phosphorylation events that are necessary for G-protein-mediated signaling, thereby disrupting GPSM3's ability to properly localize and function. The inhibition of PKC can essentially decouple GPSM3 from its signaling cascade, affecting the protein's regulatory competence in cellular processes. Similarly, ML-141, which selectively targets Cdc42 GTPase, can alter cell polarity signaling pathways. Since GPSM3 is implicated in the regulation of cell polarity and migration through its interaction with G-proteins, inhibiting Cdc42 with ML-141 can indirectly affect GPSM3's functional role within the cell.
In parallel, Y-27632, a selective inhibitor of Rho-associated kinase (ROCK), can alter the actin cytoskeleton organization. Given GPSM3's role in the regulation of cell polarity and cytoskeletal organization, the inhibition of ROCK can interfere with cellular processes that are under the control of GPSM3. Wiskostatin, which targets N-WASP, can also disrupt actin dynamics and thus impinge upon GPSM3's ability to regulate structural organization within the cell. NSC23766 inhibits Rac1 GTPase and can thereby influence cytoskeletal dynamics and cell migration, processes in which GPSM3 is known to be involved. Additionally, PD 98059 and LY294002 inhibit MEK and phosphoinositide 3-kinases (PI3K), respectively, which are part of signaling pathways GPSM3 may modulate. The inhibition of these kinases can impede the activation of downstream pathways, affecting GPSM3's regulatory actions. Lastly, KT 5720 and SB 203580 inhibit protein kinase A (PKA) and p38 MAP kinase, respectively, both of which can influence G-protein signaling pathways and stress response signaling cascades that GPSM3 is a part of, thus impacting the functional capabilities of GPSM3 in cellular signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide is a potent and selective inhibitor of protein kinase C (PKC), which is involved in the activation of G-proteins. Since GPSM3 regulates G-protein signaling, inhibition of PKC can disrupt the phosphorylation events that are necessary for G-protein-mediated signaling, thereby functionally inhibiting GPSM3 by preventing its proper localization and function within the cell. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated kinase (ROCK), which plays a role in actin cytoskeleton organization. GPSM3 interacts with Gα subunits and is implicated in the regulation of cell polarity and cytoskeletal organization. By inhibiting ROCK, Y-27632 can disrupt the actin cytoskeleton, potentially impeding the cellular processes that GPSM3 is involved in regulating. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML-141 is a potent and selective inhibitor of Cdc42 GTPase. GPSM3 has been shown to influence cell polarity and migration through interactions with G-proteins. Cdc42 is a key regulator of cell polarity, and its inhibition by ML-141 can lead to disrupted cell polarity signaling, thereby indirectly inhibiting the functional role of GPSM3 in the cell. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a broad-spectrum protein kinase C (PKC) inhibitor. By blocking PKC activity, Go 6983 can prevent the phosphorylation and activation of downstream components in G-protein signaling pathways, of which GPSM3 is a part. This results in the functional inhibition of GPSM3 by limiting its ability to modulate G-protein signaling within the cell. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an inhibitor of the actin-regulating protein N-WASP. Given that GPSM3 is involved in the regulation of the cytoskeleton through G-proteins, the inhibition of N-WASP by Wiskostatin can result in disrupted actin dynamics and cellular processes that GPSM3 helps to regulate, functionally inhibiting the effects of GPSM3 on the cell's structural organization. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is upstream of the ERK pathway. GPSM3 is involved in G-protein-mediated signaling pathways that can intersect with ERK signaling. By inhibiting MEK, PD 98059 can suppress ERK pathway activation, which could disrupt signaling processes that GPSM3 is involved in, thereby functionally inhibiting GPSM3's role in those pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling is important for a variety of cellular functions, including those regulated by G-proteins. Since GPSM3 is involved in G-protein signaling, the inhibition of PI3K by LY294002 can disrupt downstream signaling events that GPSM3 may regulate, thus functionally inhibiting GPSM3. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT 5720 is an inhibitor of protein kinase A (PKA). PKA is a key regulator of numerous G-protein signaling pathways. The inhibition of PKA by KT 5720 can prevent the phosphorylation of proteins that are involved in processes regulated by GPSM3, leading to the functional inhibition of GPSM3 by impeding its ability to regulate those processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is an inhibitor of p38 MAP kinase, which is involved in cellular stress responses. GPSM3 is implicated in G-protein-mediated signaling pathways that can be affected by stress responses. | ||||||