GPR32 Activators
GPR32 Activators are various compounds that serve to enhance the receptor's functional activity through different biochemical mechanisms and signaling pathways. Forskolin, by promoting adenylate cyclase activity, raises intracellular cAMP, which activates PKA, subsequently leading to the phosphorylation and enhanced activity of GPR32. This process is supported by Isoproterenol,a beta-adrenergic agonist that similarly increases cAMP and indirectly supports GPR32 activity. PGE2 may engage GPR32, stimulating cAMP and PKA pathways, while IBMX sustains elevated cAMP by inhibiting its degradation, thereby potentiating GPR32 signaling. Zn2+ can act as an allosteric enhancer of GPR32, inducing structural changes that bolster receptor responsiveness. Anandamide may serve as an agonist, directly activating GPR32 or altering its conformation to increase activity.
LPA and Sphingosine-1-phosphate, through their respective GPCR interactions, could modulate the cellular milieu to favor GPR32 activity, either by direct receptor cross-activation or sensitization via shared signaling intermediates. Adenosine, by activating its receptors, could impact GPR32 through indirect means such as heterologous desensitization or shared cAMP pathways. Capsaicin stimulates TRPV1 receptors and may elicit the release of endogenous GPR32 agonists or alter intracellular calcium, indirectly enhancing GPR32 signaling. Oxytocin, through its receptor, affects calcium signaling pathways, which could lead to a permissive or stimulatory state for GPR32 activity. Lastly, Nicotinic acid acts on GPR109A, which may have downstream effects that inadvertently support GPR32's functional state due to pathway crosstalk or common signaling effectors, highlighting the intricate web of inter-receptor influences and the complexity of cellular signaling networks in modulating receptor activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA). PKA can then phosphorylate its target proteins, which may include GPR32 or proteins associated with GPR32 signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate interacts with G-protein-coupled receptors, potentially including GPR32. S1P binding can lead to downstream signaling cascades that result in cellular responses such as proliferation, survival, and migration, which may involve GPR32. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist. It can stimulate GPR32 as it can lead to increased levels of cAMP in cells, which in turn can activate PKA. PKA activation could result in phosphorylation and activation of GPR32 directly or its associated pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases, which may result in the activation of GPR32 through phosphorylation or through the activation of pathways in which GPR32 is involved. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein-coupled receptors, which could include GPR32. PGE2 receptor activation leads to various downstream effects, including the elevation of cAMP, potentially enhancing the functional activity of GPR32. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Bromo-cAMP) is a cAMP analog that can activate PKA. By activating PKA, 8-Bromo-cAMP might enhance GPR32 signaling if GPR32 is modulated by PKA phosphorylation or if it's part of the cAMP-dependent signaling pathways. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with its G-protein-coupled adenosine receptors, which could include GPR32, leading to various downstream signaling events such as cAMP accumulation. This could enhance GPR32 activity directly or through related signaling pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine stimulates its G-protein-coupled histamine receptors, which could include GPR32. This stimulation can lead to the activation of phospholipase C, increasing intracellular calcium, which could, in turn, activate GPR32. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine interacts with dopamine receptors, which are G-protein-coupled receptors and could include GPR32. Dopamine receptor activation can result in the modulation of cAMP and other second messengers, potentially leading to the activation of GPR32. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $520.00 | 3 | |
3-(2-Aminoethyl)-1H-indol-5-ol (Serotonin) binds to serotonin receptors, which are part of the G-protein-coupled receptor family and could include GPR32. Activation of these receptors can result in various downstream signaling cascades, potentially leading to the activation of GPR32. | ||||||