GPR18 Activators

GPR18 Activators encompass a variety of chemical compounds that directly influence GPR18's role in G protein-coupled receptor signaling, leading to various physiological effects. Anandamide and Abnormal cannabidiol are notable for their high affinity to GPR18, effectively initiating G protein-mediated signaling cascades, which result in increased intracellular calcium levels, thus enhancing GPR18's functional activity. Similarly, O-1602 and N-Arachidonoyl glycine specifically bind to GPR18, facilitating the receptor's G protein-coupled intracellular pathways and upregulating GPR18 activity. Resolvin D2, a specialized pro-resolving mediator, interacts with GPR18 to initiate anti-inflammatory signaling that includes GPR18 activation, while 12(S)-HETrE, a hydroxyeicosatetraenoic acid derivative, stimulates GPR18-related signaling, adding to the activation of this receptor.

Further contributing to the activation of GPR18, PSB-6160 functions as an agonist, triggering downstream signaling events that elevate GPR18 activity through G protein-coupled mechanisms. Cannabidiol, although less specific, has been observed to interact with GPR18 and potentially enhance its signaling function along with its primary interactions with other cannabinoid receptors. Arachidonic acid, through its metabolism into various eicosanoids, may also serve as a GPR18 activator, promoting the protein's role in modulating inflammatory and immune responses. Additionally, Oleamide, Alpha-linolenic acid, and Linoleic acid, through their interactions with GPR18, are implicated in the regulation of sleep, thermoregulation, and the generation of bioactive metabolites,respectively, which could potentiate GPR18's associated signaling pathways.