N-Arachidonoyl glycine (CAS 179113-91-8)
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N-Arachidonoyl glycine is a compound that functions as an endogenous lipid mediator. It acts as a ligand for the G protein-coupled receptor GPR18, modulating its activity. This interaction with GPR18 is involved in various physiological processes, including immune response, inflammation, and pain perception. N-Arachidonoyl glycine is also known to have a role in the regulation of lipid metabolism and energy homeostasis. At the molecular level, N-Arachidonoyl glycine (neat powder) exerts its effects by binding to and activating GPR18, leading to downstream signaling cascades within cells. This activation of GPR18 by N-Arachidonoyl glycine may influence intracellular pathways and gene expression, ultimately impacting cellular function and physiological responses. N-Arachidonoyl glycine plays a functional role in cellular signaling and modulation of physiological processes through its interaction with GPR18.
N-Arachidonoyl glycine (CAS 179113-91-8) References
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- N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. | McHugh, D., et al. 2010. BMC Neurosci. 11: 44. PMID: 20346144
- N-arachidonoyl glycine induces macrophage apoptosis via GPR18. | Takenouchi, R., et al. 2012. Biochem Biophys Res Commun. 418: 366-71. PMID: 22266325
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- siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration. | McHugh, D., et al. 2012. J Mol Signal. 7: 10. PMID: 22834922
- The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1-Orai1 interaction. | Deak, AT., et al. 2013. J Cell Sci. 126: 879-88. PMID: 23239024
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- Δ(9)-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18. | McHugh, D., et al. 2014. Front Pharmacol. 4: 162. PMID: 24427137
- GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine. | Finlay, DB., et al. 2016. PeerJ. 4: e1835. PMID: 27018161
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Arachidonoyl glycine, 5 mg | sc-362169 | 5 mg | $112.00 | |||
N-Arachidonoyl glycine, 25 mg | sc-362169A | 25 mg | $187.00 |