Molecular structure of Resolvin D2, CAS Number: 810668-37-2
Resolvin D2 (CAS 810668-37-2)
See product citations (2)
Application:
Resolvin D2 is a lipid mediator
CAS Number:
810668-37-2
Purity:
≥95%
Molecular Weight:
376.5
Molecular Formula:
C22H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation. It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM. Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.
Resolvin D2 (CAS 810668-37-2) References
- Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway. | Deyama, S., et al. 2017. Int J Neuropsychopharmacol. 20: 575-584. PMID: 28419244
- Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke. | Dong, X., et al. 2019. ACS Nano. 13: 1272-1283. PMID: 30673266
- Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization. | Shan, K., et al. 2020. J Cell Mol Med. 24: 8045-8056. PMID: 32469149
- Resolvin D2 prevents inflammation and oxidative stress in the retina of streptozocin-induced diabetic mice. | Chen, JP., et al. 2020. Int J Clin Exp Pathol. 13: 1986-1994. PMID: 32922593
- Resolvin D2 attenuates chronic pain-induced depression-like behavior in mice. | Suzuki, H., et al. 2021. Neuropsychopharmacol Rep. 41: 426-429. PMID: 34291613
- Resolvin D2 suppresses NLRP3 inflammasome by promoting autophagy in macrophages. | Cao, L., et al. 2021. Exp Ther Med. 22: 1222. PMID: 34603519
- Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy. | Dort, J., et al. 2021. Nat Commun. 12: 6264. PMID: 34716330
- Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection. | Walker, JM., et al. 2022. Prostaglandins Other Lipid Mediat. 159: 106617. PMID: 35007703
- Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca2+]i Increase and Mucin Secretion in Conjunctival Goblet Cells. | Yang, M., et al. 2021. Int J Mol Sci. 23: PMID: 35008563
- The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice. | Bardin, M., et al. 2022. Biochem Pharmacol. 201: 115075. PMID: 35525326
- Resolvin D2 uses multiple Ca2+ -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells. | Botten, N., et al. 2022. J Cell Physiol. 237: 3816-3833. PMID: 36066128
- Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension. | Díaz Del Campo, LS., et al. 2023. Hypertension. 80: 84-96. PMID: 36337053
- Resolvin D2 induces anti-microbial mechanisms in a model of infectious peritonitis and secondary lung infection. | Sundarasivarao, PYK., et al. 2022. Front Immunol. 13: 1011944. PMID: 36532055
Activator of:
GPR18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Resolvin D2, 10 µg | sc-351847 | 10 µg | $196.00 | |||
Resolvin D2, 25 µg | sc-351847A | 25 µg | $464.00 |