GPR154 Activators
GPR154 Activators are a diverse group of compounds that indirectly modulate the activity or expression of GPR154 by interacting with various cellular signaling mechanisms. Forskolin, Isoproterenol, Rolipram, and IBMX operate primarily by increasing intracellular cAMP, a second messenger that regulates G protein-coupled receptor (GPCR) signaling, which could enhance GPR154 activity or expression. These compounds activate or inhibit enzymes involved in the synthesis or degradation of cAMP, thus modifying the signaling environment in which GPR154 functions.
Compounds like Sodium butyrate, 5-Azacytidine, SB216763, and Trichostatin A exert their effects on GPR154 by altering gene expression. They act epigenetically, either by inhibiting histone deacetylases or DNA methyltransferases, to potentially change the expression level of GPR154. Zinc Pyrithione might influence GPR154 by altering ion gradients across the cell membrane, which can affect GPCR function. Chelerythrine and Flufenamic acid, by modulating the activity of PKC and influencing GPCR-related signaling, respectively, might lead to changes in GPR154 activity. Lastly, Bay K8644 can elevate intracellular calcium levels, which could indirectly influence the calcium-dependent regulation of GPR154.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP, which can enhance the sensitivity of GPCRs including GPR154. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that can upregulate cAMP production, possibly affecting GPR154. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A phosphodiesterase inhibitor, which prevents cAMP breakdown, potentially affecting GPR154 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective phosphodiesterase inhibitor, which can increase cAMP levels, and may influence GPR154 function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor that may lead to changes in gene expression, possibly affecting GPR154. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that may lead to gene demethylation, potentially affecting GPR154 expression. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
A GSK-3 inhibitor, could modulate Wnt signaling, possibly influencing the expression of GPR154. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that may alter chromatin structure and affect GPR154 gene expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
May modulate GPCR function by affecting transmembrane metal ion gradients, indirectly influencing GPR154. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
A PKC inhibitor that may lead to compensatory changes in GPCR function, possibly affecting GPR154. | ||||||