Date published: 2026-4-1

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GPR105 Activators

GPR105 activators largely revolve around the modulation of purinergic signaling, given the receptor's nature and its known interactions with nucleotide sugars like UDP-Glucose. Among these activators, UDP-Glucose stands out as a direct agonist, ensuring receptor activation upon binding. Its related nucleotide, Uridine diphosphate, showcases the relevance of nucleotide-like structures in influencing GPR105. Adenosine and its derivatives, such as NECA, impact purinergic receptor signaling, suggesting an indirect route to influence GPR105. Alloxazine's potential influence on GPR105 arises from its modulation of purinergic signaling pathways, a theme that resonates across several of these activators.The inclusion of compounds like Suramin highlights the intricate balance between antagonism and agonism in receptor biology. While primarily antagonists, in specific contexts, their presence can modulate GPR105 activation, likely due to crosstalk between signaling pathways or cellular compensatory mechanisms.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MRS 2690

15039-58-4sc-204104
1 mg
$398.00
(0)

MRS 2690 is a selective GPR105 activator that engages in unique molecular interactions, promoting receptor dimerization and subsequent downstream signaling cascades. Its distinct structural features facilitate high-affinity binding, enhancing receptor activation and influencing cellular responses. The compound exhibits notable reaction kinetics, characterized by rapid onset and sustained effects, which are critical for modulating various physiological processes. Its behavior as an acid halide further underscores its reactivity and potential for diverse applications in biochemical research.

Uridine 5′-diphosphoglucose disodium salt from Saccharomyces cerevisiae

28053-08-9sc-222402
sc-222402A
10 mg
25 mg
$27.00
$34.00
(0)

Uridine 5'-diphosphoglucose disodium salt, derived from Saccharomyces cerevisiae, acts as a GPR105 activator by engaging in specific molecular interactions that enhance receptor sensitivity. Its unique phosphate and sugar moieties facilitate effective binding, triggering intricate signaling pathways. The compound demonstrates distinct reaction kinetics, allowing for a swift activation profile that influences cellular dynamics. Its role in metabolic pathways highlights its importance in cellular energy regulation and signaling modulation.

Uridine-5′-diphosphoglucose, disodium salt

117756-22-6sc-296687
sc-296687A
sc-296687B
sc-296687C
sc-296687D
sc-296687E
100 mg
1 g
10 g
50 g
100 g
1 kg
$99.00
$458.00
$2611.00
$13015.00
$16657.00
$41106.00
1
(1)

Uridine-5'-diphosphoglucose, disodium salt, serves as a GPR105 activator through its ability to form stable complexes with receptor sites, promoting conformational changes that enhance downstream signaling. The compound's dual phosphate groups contribute to its high affinity for GPR105, facilitating rapid signal transduction. Additionally, its structural characteristics allow for versatile interactions within cellular environments, influencing various metabolic processes and regulatory mechanisms.

Uridine 5′-diphosphate sodium salt

21931-53-3sc-222401
sc-222401A
25 mg
100 mg
$38.00
$79.00
(0)

An associated nucleotide that might modulate GPR105 activity, given its structural similarity to UDP-Glucose.

Adenosine

58-61-7sc-291838
sc-291838A
sc-291838B
sc-291838C
sc-291838D
sc-291838E
sc-291838F
1 g
5 g
100 g
250 g
1 kg
5 kg
10 kg
$34.00
$48.00
$300.00
$572.00
$1040.00
$2601.00
$4682.00
1
(0)

A purine nucleoside that can modulate purinergic receptor activity, which includes GPR105.

Alloxazine

490-59-5sc-252358
1 g
$51.00
(1)

Can modulate purinergic receptor signaling and may indirectly influence GPR105.

Suramin sodium

129-46-4sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$152.00
$214.00
$728.00
$2601.00
$10965.00
$21838.00
$41096.00
5
(1)

A known antagonist of purinergic receptors. In certain contexts, it may modulate GPR105 activation.

MRS 2179 ammonium salt

101204-49-3sc-253058
5 mg
$313.00
1
(0)

A purinergic receptor antagonist that, due to its influence on purinergic signaling, might affect GPR105.