Date published: 2025-12-8

1-800-457-3801

SCBT Portrait Logo
Seach Input

Alloxazine (CAS 490-59-5)

5.0(1)
Write a reviewAsk a question

Alternate Names:
Isoalloxazine
Application:
Alloxazine is a selective Adenosine A2B-R (A2B adenosine receptor) antagonist
CAS Number:
490-59-5
Molecular Weight:
214.18
Molecular Formula:
C10H6N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Alloxazine is a chemical compound that functions as a cofactor in various enzymatic reactions. It plays a role in electron transfer processes within biological systems, facilitating the transfer of electrons from one molecule to another. Alloxazine interacts with specific enzymes to assist in the conversion of substrates into products, contributing to the efficiency of the biochemical pathways in which it participates. At the molecular level, alloxazine undergoes redox reactions, shuttling electrons between different molecules to drive cellular processes. Its mechanism of action involves binding to specific enzyme active sites and participating in the transfer of electrons, ultimately influencing the rate and direction of metabolic reactions. In this way, alloxazine contributes to the regulation and coordination of various biochemical pathways, supporting the function and homeostasis of biological systems.


Alloxazine (CAS 490-59-5) References

  1. Alloxazine as a ligand for selective binding to adenine opposite AP sites in DNA duplexes and analysis of single-nucleotide polymorphisms.  |  Rajendar, B., et al. 2008. Org Biomol Chem. 6: 670-3. PMID: 18264565
  2. Electron ionization mass spectrometric study of substituted alloxazine-5-oxides and iso-alloxazine-5-oxide.  |  Prukała, D. and Sikorski, M. 2009. Rapid Commun Mass Spectrom. 23: 619-28. PMID: 19165754
  3. The photophysics of alloxazine: a quantum chemical investigation in vacuum and solution.  |  Salzmann, S. and Marian, CM. 2009. Photochem Photobiol Sci. 8: 1655-66. PMID: 20024162
  4. Effect of substituents of alloxazine derivatives on the selectivity and affinity for adenine in AP-site-containing DNA duplexes.  |  Rajendar, B., et al. 2010. Org Biomol Chem. 8: 4949-59. PMID: 20820650
  5. Nitric oxide synthase/K+ channel cascade triggers the adenosine A(2B) receptor-sensitive renal vasodilation in female rats.  |  El-Gowelli, HM., et al. 2013. Eur J Pharmacol. 702: 116-25. PMID: 23396225
  6. A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors.  |  Virus, RM., et al. 1990. Neuropsychopharmacology. 3: 243-9. PMID: 2400543
  7. Structure and general properties of flavins.  |  Edwards, AM. 2014. Methods Mol Biol. 1146: 3-13. PMID: 24764085
  8. Revelation of varying bonding motif of alloxazine, a flavin analogue, in selected ruthenium(II/III) frameworks.  |  Mondal, P., et al. 2015. Inorg Chem. 54: 3012-21. PMID: 25738881
  9. QM/MM Study on Mechanistic Photophysics of Alloxazine Chromophore in Aqueous Solution.  |  Chang, XP., et al. 2016. J Phys Chem A. 120: 6129-36. PMID: 27420290
  10. Observation of Near-Threshold Resonances in the Flavin Chromophore Anions Alloxazine and Lumichrome.  |  Matthews, E. and Dessent, CEH. 2018. J Phys Chem Lett. 9: 6124-6130. PMID: 30277786
  11. Vibrational spectroscopy of flavoproteins.  |  Iuliano, JN., et al. 2019. Methods Enzymol. 620: 189-214. PMID: 31072487
  12. Computer and Experimental Simulation of Alloxazine Synthesis from Gamma Irradiation of Amino Acids on Iceland Spar: A Prebiotic Chemistry Perspective.  |  Mendoza-Torres, E., et al. 2020. J Mol Evol. 88: 284-291. PMID: 32140772
  13. A quantitative evaluation of computational methods to accelerate the study of alloxazine-derived electroactive compounds for energy storage.  |  Zhang, Q., et al. 2021. Sci Rep. 11: 4089. PMID: 33603045
  14. [Riboflavin and lumiflavin analogs and alloxazine derivatives. I. Effect on riboflavin synthesis by and growth of Bacillus subtilis].  |  Stepanov, AI., et al. 1975. Genetika. 11: 116-24. PMID: 814049

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alloxazine, 1 g

sc-252358
1 g
$51.00