GPR-152 Activators
GPR-152 include a range of compounds that enhance the intracellular signaling pathways, particularly those that increase cyclic AMP (cAMP) levels within cells. Forskolin is one such activator, which directly stimulates adenylyl cyclase, the enzyme responsible for converting ATP to cAMP. By increasing cAMP production, forskolin can effectively activate GPR-152, as the receptor is modulated by cAMP levels. Similarly, Isoproterenol, a non-selective beta-adrenergic agonist, also raises cAMP levels by activating beta-adrenergic receptors, which in turn can activate GPR-152. Adrenergic agonists like Epinephrine and the selective β2-agonists Salbutamol and Terbutaline operate on similar principles, binding to adrenergic receptors and elevating cAMP, thus stimulating GPR-152. These mechanisms demonstrate the role of beta-adrenergic receptor-mediated pathways in the activation of GPR-152.
The activation of GPR-152 is also influenced by other chemicals that interact with various G protein-coupled receptors (GPCRs), leading to increased cAMP levels. PGE1 and PGE2, prostaglandins that bind to their respective receptors, activate GPR-152 by increasing cAMP through receptor-mediated pathways. NECA (5'-N-Ethylcarboxamidoadenosine), as a potent adenosine receptor agonist, and Adenosine itself, through adenosine receptors, elevate cAMP, thus activating GPR-152. Histamine and Dopamine, by binding to their specific histamine and dopamine receptors, respectively, can modulate intracellular signaling networks that may result in the activation of GPR-152. IBMX, which inhibits phosphodiesterases and prevents the degradation of cAMP, results in sustained levels of cAMP that can activate GPR-152. Collectively, these chemicals utilize the cAMP-dependent signaling pathway to modulate the activity of GPR-152, demonstrating the intricate interplay between different signaling molecules and receptors in cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP) within cells. GPR-152 is a G protein-coupled receptor, and its activity can be modulated by intracellular levels of cAMP, thereby leading to its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases cAMP levels by activating beta-adrenergic receptors, which can enhance the activity of GPR-152 through increased cAMP signaling. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Prostaglandin E1 binds to and activates its cognate G protein-coupled receptors, which can lead to an increase in intracellular cAMP levels. This rise in cAMP can activate GPR-152 via downstream signaling cascades. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to and activate histamine receptors, which are G protein-coupled receptors that, through their signaling pathways, can result in the activation of other GPCRs such as GPR-152 by modulating intracellular signaling networks. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine activates adenosine receptors, which are G protein-coupled receptors, and this can lead to increased intracellular cAMP levels, subsequently activating GPR-152 through cAMP-dependent pathways. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can activate dopamine receptors, another class of G protein-coupled receptors, which can influence cAMP production and thereby activate GPR-152 as part of the signaling cascade. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to and activates adrenergic receptors leading to increased cAMP levels within cells. Elevated cAMP can then activate GPR-152 through the cAMP-dependent signaling pathway. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a selective β2-adrenergic receptor agonist that increases cAMP production in the cell, potentially leading to the activation of GPR-152 through enhanced cAMP signaling. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline acts as a β2-agonist, stimulating adenylyl cyclase activity and increasing cAMP levels, which can lead to the activation of GPR-152 via the cAMP-dependent signaling pathway. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 activates its own G protein-coupled receptors which can lead to an increase in intracellular cAMP levels, thereby activating GPR-152 through cAMP-mediated signaling pathways. | ||||||