GOLGA8O Inhibitors
GOLGA8O inhibitors belong to a specific chemical class designed to modulate the activity of the Golgin subfamily A member 8O (GOLGA8O) protein. The GOLGA8O protein, part of the golgin family localized to the Golgi apparatus, plays a crucial role in intracellular vesicle trafficking and maintaining the structural integrity of the Golgi complex. The Golgi apparatus serves as a central hub for post-translational modification, sorting, and packaging of proteins before they are transported to their designated cellular destinations. GOLGA8O, in particular, is implicated in tethering vesicles to the Golgi membrane, facilitating the proper functioning of this cellular organelle.
Inhibitors targeting GOLGA8O are designed to interfere with its molecular interactions and regulatory functions. By modulating the activity of GOLGA8O, these inhibitors aim to influence the dynamics of vesicle transport within the cell, potentially impacting various cellular processes reliant on the proper functioning of the Golgi apparatus. The development of GOLGA8O inhibitors reflects a broader interest in understanding and manipulating intracellular transport mechanisms, with implications for basic cell biology research. Further exploration of these inhibitors may contribute to a more comprehensive understanding of cellular dynamics and could potentially uncover novel avenues for the modulation of intracellular trafficking events.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus by inhibiting ADP-ribosylation factor (ARF), a small GTPase essential for Golgi vesicle trafficking. This perturbation affects GOLGA8O by destabilizing the Golgi structure, indirectly leading to its functional inhibition. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a polyether antibiotic that disrupts Golgi function by altering the pH within Golgi compartments, affecting protein sorting and trafficking. This mode of action can impede the proper functioning of GOLGA8O by interfering with its Golgi-associated processes. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Golgicide A specifically targets the Golgi brefeldin A resistant guanine nucleotide exchange factor 1 (GBF1), disrupting Golgi apparatus structure and function. This compound indirectly inhibits GOLGA8O by impairing the organelle it associates with. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which affects the microtubule-dependent trafficking of vesicles to and from the Golgi complex. This interference can indirectly inhibit GOLGA8O activity by disturbing its localization and function related to the Golgi. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation by blocking the first step in the synthesis of the dolichol-linked oligosaccharide precursor. This action can indirectly decrease GOLGA8O function by affecting the glycosylation processes required for its stability and activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, which is critical for Golgi function and vesicle transport. By disrupting microtubule dynamics, Colchicine can indirectly decrease GOLGA8O activity by impeding its associated trafficking functions. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a small molecule that inhibits dynamin, a GTPase involved in endocytosis and vesicle trafficking. This inhibition can result in the functional downregulation of GOLGA8O by disrupting vesicular transport processes that are critical for its activity. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $87.00 $282.00 | 1 | |
Exo2 is an inhibitor of the Sec7 domain of GBF1, which is essential for vesicle trafficking within the Golgi. By inhibiting GBF1, Exo2 can indirectly lead to the inhibition of GOLGA8O by disrupting the Golgi apparatus structure and vesicle transport processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, preventing their disassembly, which is essential for normal Golgi function and positioning. Through its action on microtubules, Paclitaxel can indirectly inhibit GOLGA8O by disrupting its normal functioning associated with the Golgi apparatus. | ||||||