GnRHR2 Inhibitors
Gonadotropin-Releasing Hormone Receptor 2 (GnRHR2) is a crucial protein primarily expressed in reproductive tissues, where it plays a pivotal role in regulating gonadotropin secretion. This receptor belongs to the G protein-coupled receptor (GPCR) family and serves as the primary mediator of the effects of gonadotropin-releasing hormone (GnRH). Through intricate signaling pathways, activation of GnRHR2 leads to downstream events culminating in the release of gonadotropins from the pituitary gland, thereby regulating essential processes such as ovulation and spermatogenesis. GnRHR2 is thus integral to the proper functioning of the reproductive system, ensuring the timely and coordinated release of hormones necessary for reproductive processes.
Inhibition of GnRHR2 is achieved through various mechanisms targeting critical signaling pathways involved in its activation and downstream effects. Key pathways implicated in this inhibition include the phosphoinositide 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), and p38 MAP kinase pathways. Chemical inhibitors disrupt these pathways by targeting specific components such as protein kinases or critical nodes, thereby impeding GnRHR2 expression and function. By interfering with these signaling cascades, inhibitors effectively downregulate GnRHR2, leading to a dampened response to GnRH stimulation. Overall, the inhibition of GnRHR2 represents a strategy to modulate reproductive function by targeting key molecular pathways involved in hormone regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Broad-spectrum protein kinase inhibitor that blocks various kinases involved in cell signaling. This leads to the downregulation of GnRHR2 through inhibition of downstream signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Phosphoinositide 3-kinase (PI3K) inhibitor which disrupts PI3K/AKT signaling pathway. Inhibition of this pathway suppresses GnRHR2 expression by interfering with its activation and downstream effects. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Potent and selective inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase activity reduces GnRHR2 expression and function by disrupting its signaling cascades. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Selective inhibitor of MAP kinase kinase (MEK) that blocks the MAPK/ERK signaling pathway. Inhibition of this pathway results in decreased expression and activity of GnRHR2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Inhibitor of MEK1 and MEK2 which are upstream activators of ERK1/2. By blocking MEK activity, U0126 suppresses the MAPK/ERK pathway, leading to downregulation of GnRHR2 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Potent inhibitor of PI3K/AKT signaling pathway. By blocking PI3K activity, LY294002 disrupts downstream signaling events essential for GnRHR2 expression and function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Selective inhibitor of c-Jun N-terminal kinase (JNK). Inhibition of JNK activity suppresses GnRHR2 expression by disrupting its downstream signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that blocks mTORC1 complex, essential for cell growth and proliferation. Inhibition of mTORC1 leads to decreased expression of GnRHR2 by disrupting protein synthesis and cell signaling. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
Potent and selective inhibitor of Akt kinase. Inhibition of Akt activity disrupts PI3K/AKT signaling pathway, resulting in downregulation of GnRHR2 expression and function. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
Potent and selective inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase activity reduces GnRHR2 expression and function by disrupting its signaling cascades. | ||||||