GnRHR2 Antibody (67-R): sc-100301

GnRHR2 Antibody (67-R) is a mouse monoclonal IgG2a kappa light chain antibody that detects GnRHR2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GnRHR2 antibody (67-R) is available as the non-conjugated form. The gonadotropin-releasing hormone (GnRH) type 2 receptor, or GnRHR2, is a critical component in regulating reproductive hormone release, functioning as a G protein-coupled receptor that mediates GnRH effects. GnRHR2 is primarily localized to the cell membrane, where GnRHR2 plays a vital role in signal transduction by activating a phosphatidylinositol-calcium second messenger system. GnRHR2′s location in the cell membrane enables rapid response to GnRH pulses, which are essential for timely synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. GnRHR2 is implicated in antiproliferative effects on ovarian and endometrial cancer cells, highlighting GnRHR2′s potential role in tumor suppression. Alternative splicing of the GnRHR2 gene results in two isoforms, which may have distinct functional roles in various tissues.

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GnRHR2 Antibody (67-R) References:

1. A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates.  |  Neill, JD., et al. 2001. Biochem Biophys Res Commun. 282: 1012-8. PMID: 11352653
2. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci.  |  Faurholm, B., et al. 2001. Genomics. 78: 15-8. PMID: 11707068
3. GnRH and GnRH receptor genes in the human genome.  |  Neill, JD. 2002. Endocrinology. 143: 737-43. PMID: 11861490
4. Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation.  |  Gründker, C., et al. 2002. J Clin Endocrinol Metab. 87: 1427-30. PMID: 11889221
5. Type II gonadotropin-releasing hormone receptor transcripts in human sperm.  |  van Biljon, W., et al. 2002. Biol Reprod. 67: 1741-9. PMID: 12444048
6. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12.  |  Morgan, K., et al. 2003. Endocrinology. 144: 423-36. PMID: 12538601
7. GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs.  |  Eicke, N., et al. 2005. Eur J Endocrinol. 153: 605-12. PMID: 16189182
8. Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors.  |  Ikemoto, T. and Park, MK. 2006. Genomics. 87: 459-62. PMID: 16406723
9. Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor.  |  Parker, JD., et al. 2007. Fertil Steril. 88: 39-46. PMID: 17296196

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GnRHR2 Antibody (67-R) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GnRHR2 Antibody (67-R) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GnRHR2 Antibody (67-R) Specifications

Alternate Product Name: GnRHR2

Product Clone Name: 67-R

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 237-293

Epitope Target: GnRHR2

Epitope Species: human

Product Reactivity/Detection: GnRHR2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GnRHR2 Antibody (67-R): N/A