GMEB-1 Activators
Glucocorticoid modulatory element-binding protein 1 (GMEB-1) is a protein that in humans is encoded by the GMEB1 gene. It is also known as Protein ARIP-3 (Activator of cAMP-responsive element modulator (CREM) in testis).GMEB-1 belongs to the KDWK family of transcription factors, which are characterized by the presence of a unique DNA-binding domain known as the KDWK domain. This domain allows these proteins to bind to specific sequences of DNA and influence gene expression.
GMEB-1 is known to bind to DNA sequences containing glucocorticoid modulatory elements (GMEs), hence its name. By binding to these sequences, GMEB-1 can modulate the transcriptional activity of associated genes, particularly in response to glucocorticoid hormones.Glucocorticoids are a type of steroid hormone that play key roles in various physiological processes, including inflammatory responses, immune function, and stress responses. By influencing the activity of genes responsive to these hormones, GMEB-1 can affect these processes.Ongoing research will help to better understand the roles of GMEB-1 in human biology and its potential implications for health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can enhance glucocorticoid receptor signaling, potentially influencing GMEB-1 activity. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Cortisol, a natural glucocorticoid, activates glucocorticoid receptors, possibly affecting GMEB-1-mediated gene regulation. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $84.00 $253.00 | 2 | |
Prednisolone is another synthetic glucocorticoid, which might indirectly modulate GMEB-1 activity through glucocorticoid receptor pathways. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
RU486, a glucocorticoid receptor antagonist, could provide insights into GMEB-1 function in the context of glucocorticoid signaling. | ||||||
Ciclesonide | 126544-47-6 | sc-207432 | 10 mg | $205.00 | 2 | |
Ciclesonide is a glucocorticoid that requires conversion to its active form, potentially affecting GMEB-1 activity. | ||||||
Budesonide | 51333-22-3 | sc-202980 sc-202980A sc-202980B sc-202980C | 50 mg 100 mg 200 mg 500 mg | $79.00 $90.00 $154.00 $350.00 | 3 | |
Budesonide, a glucocorticoid used in asthma management, might indirectly affect GMEB-1 activity. | ||||||
Beclomethasone Dipropionate | 5534-09-8 | sc-210864 | 250 mg | $52.00 | ||
Beclomethasone is another glucocorticoid that could modulate GMEB-1 function via glucocorticoid receptor pathways. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aminoglutethimide inhibits glucocorticoid synthesis and could provide insights into GMEB-1 function under reduced glucocorticoid levels. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole, an antifungal with glucocorticoid synthesis inhibitory effects, might indirectly influence GMEB-1. | ||||||
Metyrapone | 54-36-4 | sc-200597 sc-200597A sc-200597B | 200 mg 500 mg 1 g | $26.00 $57.00 $88.00 | 4 | |
Metapyrone inhibits cortisol synthesis, potentially affecting GMEB-1 activity in response to altered glucocorticoid levels. | ||||||