Gm595 Activators
Fsip2l activators comprise a diverse group of chemical agents that interact with and modulate the activity of the fibrous sheath-interacting protein 2-like (FSIP2L). This protein is of particular interest due to its association with the structural integrity and function of cellular components. The activators of FSIP2L are not confined to a single chemical class; instead, they span a range of compounds that share the common ability to enhance the biological activity of FSIP2L. These activators may function through direct interaction with the protein or by influencing signaling pathways that lead to an upregulation of FSIP2L activity. The chemical structures of these activators can be quite varied, encompassing small molecules, peptides, or even larger biomolecules that can cross the cellular membrane or may require specific transport mechanisms to reach their site of action.
The mechanisms by which FSIP2L activators exert their effects are multifaceted and often involve complex biochemical pathways. Some may bind directly to FSIP2L, causing a conformational change that results in increased protein activity. Others may interact with cell surface receptors or enzymes that catalyze the production of secondary messengers, thereby initiating a cascade of intracellular events culminating in the activation of FSIP2L. Additionally, these molecules can influence the expression levels of FSIP2L by modulating the transcriptional machinery or by stabilizing the mRNA, leading to increased protein synthesis. The diversity in the action of FSIP2L activators reflects the intricate network of cellular processes they are involved with.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP can enhance PKA activity, which may phosphorylate substrates involved in sperm motility, a process FSIP2L is associated with. Thus, by increasing cAMP, Forskolin can indirectly enhance FSIP2L activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in the modulation of cytoskeletal organization. Since FSIP2L is implicated in structural aspects of sperm cells, PKC activation can enhance the functional role of FSIP2L in maintaining structural integrity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenoceptor agonist that increases cAMP levels, similar to Forskolin. The rise in cAMP can subsequently enhance PKA activity, potentially influencing the phosphorylation state of proteins related to FSIP2L function in sperm motility and structure. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels. This can amplify the signaling cascades FSIP2L might interact with, particularly in pathways regulating sperm motility, thus indirectly enhancing FSIP2L activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that can activate PKA. As PKA influences various cellular processes, including those related to sperm motility and structure, db-cAMP can indirectly enhance FSIP2L functionality by modulating these processes. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase, leading to the production of nitric oxide (NO). NO can modulate cGMP levels and thus influence pathways that regulate sperm motility, potentially enhancing the activity of FSIP2L. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is essential for spermatogenesis and may influence the structural stability of sperm. Given FSIP2L's role in sperm structure, zinc can indirectly enhance FSIP2L activity by stabilizing the cellular context in which FSIP2L operates. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression and is crucial for spermatogenesis. By influencing the cellular environment of sperm development, retinoic acid could indirectly enhance FSIP2L activity by optimizing conditions for its function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. These pathways could influence the function of FSIP2L by modulating the cellular processes it is involved in, such as sperm motility and structural integrity. | ||||||