Gm514 Activators
The chemical class known as UBAP1L activators refers to a group of compounds that have the ability to modulate the activity of ubiquitin-associated protein 1-like (UBAP1L). UBAP1L is a protein that is believed to play a role in the ubiquitin-proteasome system (UPS), a cellular machinery crucial for protein degradation and turnover. The exact mechanisms through which these activators exert their action on UBAP1L are not universally characterized; however, they are thought to interact with the protein or its associated pathways in a manner that enhances its native function.
The activators can be diverse in structure and origin, ranging from small organic molecules to more complex biological entities. They may interact directly with UBAP1L, altering its conformational state to increase its affinity or specificity for interaction partners, or they could act on upstream regulatory pathways to increase UBAP1L expression levels or stability, thus indirectly enhancing its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially leading to the accumulation and stabilization of UPS components, including UBAP1L, enhancing its functional activity by increasing its interactions with other proteins in the UPS. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is a ubiquitin-activating enzyme E1 inhibitor, which leads to a reduction in ubiquitin conjugation. This can result in altered degradation signals within the UPS, which may stabilize UBAP1L and enhance its functional activity by modifying ubiquitination dynamics. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 inhibits the NEDD8-activating enzyme, which is crucial for neddylation that controls ubiquitin E3 ligase activity. By modulating the neddylation process, MLN4924 can indirectly enhance the functional activity of UBAP1L through altered UPS-related protein turnover. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1 is an inhibitor of the deubiquitinase USP14, which can enhance the degradation rate of ubiquitinated proteins by the proteasome. Inhibition by IU1 could lead to increased levels of ubiquitinated proteins, potentially enhancing the functional activity of UBAP1L in the UPS. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a dipeptidyl boronic acid analog that inhibits the 26S proteasome. By reducing proteasomal degradation, bortezomib can indirectly enhance the functional activity of UBAP1L by increasing the pool of ubiquitinated proteins that UBAP1L may interact with. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome, leading to the accumulation of ubiquitinated proteins. This accumulation can enhance the functional activity of UBAP1L by increasing its potential substrates and interaction partners within the UPS. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a selective proteasome inhibitor that leads to increased ubiquitinated proteins levels. This can enhance the functional activity of UBAP1L by indirectly increasing its involvement in the UPS due to elevated ubiquitinated substrate availability. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid can induce the production of reactive oxygen species (ROS), which could lead to oxidative damage and the need for increased protein degradation. This could enhance the functional activity of UBAP1L by increasing its engagement in the UPS to remove damaged proteins. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is known to inhibit the proteasomal activity, leading to the build-up of ubiquitinated proteins. This accumulation might indirectly enhance the functional activity of UBAP1L by elevating the interaction with ubiquitinated proteins within the UPS. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can bind to and inhibit components of the proteasome, leading to an increase in ubiquitinated proteins. This could enhance the functional activity of UBAP1L by increasing its interactions with these proteins as part of the UPS. | ||||||