Date published: 2026-5-22

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GM2/GD2 Synthase Inhibitors

GM2/GD2 Synthase inhibitors, while not directly established, are compounds that can indirectly affect the enzyme's activity through modulation of various pathways in glycosphingolipid metabolism and cellular signaling. These inhibitors include both specific enzyme inhibitors and broader pathway modulators. The enzyme plays a crucial role in the synthesis of GM2 and GD2 gangliosides, which are involved in cellular communication and neurological development. The above-listed compounds operate through different mechanisms. For instance, Miglustat and Eliglustat inhibit glucosylceramide synthase, impacting the precursor availability for GM2/GD2 synthesis. Genistein and PDMP, by altering glycosphingolipid synthesis, can indirectly influence GM2/GD2 levels.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein, an isoflavone from soy, has been shown to inhibit glycosphingolipid synthesis, possibly affecting GM2/GD2 production.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$65.00
$280.00
$400.00
48
(2)

AMPK activators like AICAR can influence lipid metabolism, which may indirectly affect GM2/GD2 synthase activity through metabolic changes.

Fumonisin B1

116355-83-0sc-201395
sc-201395A
1 mg
5 mg
$200.00
$680.00
18
(1)

Fumonisin B1, a mycotoxin, inhibits ceramide synthase, which could indirectly influence GM2/GD2 synthase activity by altering sphingolipid levels.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic Acid, a metabolite of Vitamin A, influences cell differentiation and may indirectly affect GM2/GD2 synthase activity in developing neural tissues.

L-β-Chloroalanine Methyl Ester Hydrochloride

17136-54-8sc-211691
100 mg
$180.00
(0)

As a cysteine synthesis inhibitor, β-Chloroalanine could indirectly affect glycosphingolipid synthesis, potentially impacting GM2/GD2 synthase.

Myriocin (ISP-1)

35891-70-4sc-201397
10 mg
$150.00
8
(2)

Myriocin, a potent inhibitor of serine palmitoyltransferase, can influence sphingolipid metabolism, potentially affecting GM2/GD2 synthase activity.

4-Hydroxyphenylretinamide

65646-68-6sc-200900
sc-200900A
5 mg
25 mg
$104.00
$315.00
(0)

Fenretinide, a synthetic retinoid, has been shown to alter lipid metabolism, which might indirectly influence GM2/GD2 synthase activity.

Tamoxifen

10540-29-1sc-208414
2.5 g
$272.00
18
(2)

Tamoxifen, primarily known for its use in breast cancer, can affect lipid metabolism, potentially influencing GM2/GD2 synthase activity.

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$26.00
$119.00
$213.00
27
(1)

Imatinib, a tyrosine kinase inhibitor, might have indirect effects on GM2/GD2 synthase through its broader influence on cellular signaling pathways.