Gm166 Activators
Cilia and flagella associated protein 119 activators consist of chemical compounds that are involved in modulating the activity of this specific protein through a variety of intracellular signaling pathways. For instance, compounds like Forskolin and Isoproterenol raise the levels of cAMP within the cell, which in turn activates protein kinase A (PKA). PKA is known for its role in the phosphorylation of a wide array of proteins, which could include those that interact with or modify cilia and flagella associated protein 119, leading to an enhancement of its activity. Moreover, the rise in intracellular calcium levels induced by agents such as Ionomycin can activate calcium-dependent kinases, which are another set of enzymes capable of modifying proteins in a way that could enhance the activity of cilia and flagella associated protein 119.
Additionally, the activation of protein kinase C (PKC) by compounds such as Phorbol 12-myristate 13-acetate (PMA) could result in the phosphorylation of proteins associated with cilia and flagella associated protein 119. On a different note, the inhibition of protein phosphatases by Okadaic Acid and Calyculin A prevents the dephosphorylation of proteins, potentially leading to a sustained or increased activity of cilia and flagella associated protein 119. Furthermore, Rolipram acts by inhibiting phosphodiesterase 4 (PDE4), which results in an accumulation of cAMP and subsequent activation of PKA, again potentially enhancing the activity of cilia and flagella associated protein 119.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that elevates intracellular Ca²⁺ levels, which can activate calcium-dependent kinases that may phosphorylate and enhance activity of cilia and flagella associated protein 119. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator that promotes phosphorylation of proteins that could interact with cilia and flagella associated protein 119, enhancing its functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Beta-adrenergic agonist that increases cAMP levels, potentially enhancing PKA activity and subsequent phosphorylation of proteins involved with cilia and flagella associated protein 119. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Cell-permeable cAMP analog that directly activates PKA, potentially enhancing the activity of cilia and flagella associated protein 119 through phosphorylation of associated proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibitor of protein phosphatases 1 and 2A, maintaining proteins in a phosphorylated state, which could enhance the activity of cilia and flagella associated protein 119. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Protein phosphatase inhibitor that could increase phosphorylation levels of proteins associated with cilia and flagella associated protein 119, thereby enhancing its activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels and activation of PKA, which may enhance the functional activity of cilia and flagella associated protein 119. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor that can lead to altered phosphorylation states of proteins that might enhance the activity of cilia and flagella associated protein 119. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
GSK-3 inhibitor, leading to the activation of the Wnt signaling pathway which can influence the post-translational modifications of proteins associated with cilia and flagella associated protein 119. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
JNK activator which could lead to phosphorylation of proteins that enhance the functional activity of cilia and flagella associated protein 119. | ||||||