GM1305 inhibitors represent a class of chemical compounds specifically designed to interfere with the function of the protein GM1305, which is known to be involved in cellular processes such as cell migration, intracellular signaling, and cellular architecture regulation. The structural characteristics of these inhibitors are diverse but typically involve motifs that enable high-affinity binding to the GM1305 protein or its associated complexes. These inhibitors can exhibit a variety of chemical backbones, such as heterocyclic scaffolds, aromatic rings, and substituted aliphatic chains, which contribute to their selective binding and modulating activity. The binding interaction is often facilitated by hydrogen bonding, hydrophobic contacts, and, in some cases, covalent attachment to specific active site residues of GM1305. By targeting key functional domains of GM1305, these inhibitors are able to disrupt its interactions with other cellular proteins and affect its normal role in cellular signaling pathways.
On a molecular level, GM1305 inhibitors often function by altering the protein's conformation or blocking specific domains crucial for its activity, thus preventing GM1305 from executing its cellular roles. Such inhibitors may be designed with specificity in mind to reduce off-target effects and unintended cellular interactions. Depending on their design, these compounds may have variable selectivity for different isoforms or homologs of GM1305, which can influence their potency and efficacy in biological studies. The chemical optimization of these inhibitors typically involves balancing their solubility, stability, and cellular permeability to enhance their performance in biological systems. Furthermore, studies of these inhibitors help elucidate the precise functional roles of GM1305 in cellular processes, providing valuable insights into its mechanisms of action and the broader biological pathways in which it plays a role. Overall, GM1305 inhibitors serve as important molecular tools in biochemical research for probing the functions and interactions of the GM1305 protein within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and prevents their disassembly, thereby inhibiting microtubule motor proteins from walking along the microtubule track. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin and inhibits its polymerization, leading to the disruption of microtubule formation and function, affecting microtubule motor activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Depolymerizes microtubules and prevents their assembly, thereby inhibiting microtubule-associated motor protein functions. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Binds to tubulin and inhibits microtubule assembly, which can interfere with microtubule motor proteins like kinesins. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Inhibits the growth phase of microtubule dynamics, affecting the function of microtubule motors by preventing proper microtubule formation. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule function by binding to tubulin, potentially affecting microtubule motor proteins by altering microtubule polymer dynamics. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Inhibits tubulin polymerization, leading to the alteration of microtubule dynamics and potential inhibition of microtubule-based motor protein activities. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Binds to tubulin and inhibits its polymerization, potentially affecting the action of microtubule motor proteins. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
Destabilizes microtubules and has been shown to inhibit microtubule motor proteins indirectly by affecting microtubule dynamics. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Specifically inhibits the motor activity of the kinesin Eg5, which may suggest potential for inhibiting similar kinesin motor proteins. | ||||||