Gm1305 Activators
Kinesin family member 28 activators are a class of compounds that indirectly enhance the activity of Kif28 through various mechanisms associated with microtubule dynamics. These compounds either stabilize microtubules, providing a consistent platform for Kif28's motor function, or they disrupt microtubule dynamics, leading to cellular responses that may upregulate Kif28 activity. For instance, Paclitaxel, Epothilone B, Taxol, and Laulimalide all act to stabilize microtubules, which is crucial for the transport functions of Kif28. The stability offered by these compounds means that Kif28 can more efficiently carry out its role in intracellular cargo transport and mitosis, as a stable microtubule network is essential for the proper function of kinesin motor proteins.
On the other hand, compounds like Nocodazole, Vinblastine, Vincristine, Colchicine, and 2-Methoxyestradiol work by disrupting microtubule polymerization or dynamics. The disruption triggers cellular signaling pathways that attempt to restore microtubule integrity, potentially leading to an increase in the activity of microtubule-associated proteins, including Kif28. This compensatory cellular response can inadvertently enhance the function of Kif28. Furthermore, the inhibition of kinesin Eg5 by compounds like S-Trityl-L-cysteine and Monastrol may lead to a cellular reliance on other kinesin proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, enhancing Kif28 function by providing durable tracks for its motor activity, essential for cellular transport. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole destabilizes microtubules, leading to cellular processes that restore microtubule integrity, potentially increasing Kif28 activity. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules, which can enhance Kif28's transport efficiency by providing a persistent substrate for its activity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly, potentially enhancing Kif28 activity by initiating cellular mechanisms to maintain microtubule function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization, potentially leading to enhanced Kif28 activity through cellular compensatory responses. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide stabilizes microtubules at a different site than paclitaxel, potentially increasing Kif28 function by ensuring available microtubule tracks. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine inhibits kinesin Eg5, which may enhance Kif28 activity by increasing dependency on Kif28 for cellular transport. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol disrupts microtubule dynamics, which can indirectly lead to enhanced Kif28 activity as part of the cellular response to maintain microtubule function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol inhibits Eg5, which may result in enhanced Kif28 activity as the cell compensates for Eg5 inhibition by upregulating other kinesins. | ||||||