Glycodelin Activators
Chemical classes known as Glycodelin activators encompass compounds that engage with cellular signaling cascades and transcriptional mechanisms to ultimately modulate the expression of the Glycodelin protein. The actions of these chemicals are rooted in their capacity to interact with specific molecular targets within the cell that are upstream of Glycodelin regulation. For instance, agents like forskolin and dibutyryl-cAMP function through the elevation of intracellular cAMP levels, leading to PKA activation, which in turn can phosphorylate transcription factors implicated in the regulation of Glycodelin expression. This sequence of events underscores the complex interplay between signaling molecules and the genetic machinery governing protein synthesis.
Furthermore, compounds such as retinoic acid and genistein exemplify the diversity of mechanisms by which Glycodelin activators operate. Retinoic acid's interaction with nuclear receptors affects the transcription of genes in a manner that can lead to changes in Glycodelin levels. On the other hand, genistein's inhibition of tyrosine kinases and modulation of hormone receptor signaling pathways present a different route through which Glycodelin expression may be influenced. The collective action of these chemicals, whether they are acting as kinase inhibitors, hormone analogs, or through other signaling pathways, converges on the transcriptional regulation of Glycodelin, demonstrating the multifaceted nature of its control within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a labdane diterpenoid found in the Indian Coleus plant, directly stimulates adenylyl cyclase, thereby increasing levels of cAMP in cells. Elevated cAMP can activate protein kinase A (PKA), which may then phosphorylate transcription factors or other proteins that regulate gene expression, including genes associated with Glycodelin expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, binds to retinoic acid receptors (RARs) which heterodimerize with retinoid X receptors (RXRs) and act as transcription factors to regulate gene expression. This receptor complex can modulate the expression of specific genes that are involved in the pathways or cellular processes that ultimately influence Glycodelin production. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog. It activates PKA, mimicking the effects of endogenous cAMP and potentially upregulating genes including those governing Glycodelin expression through the activation of cAMP response element-binding (CREB) proteins which are transcription factors. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and acts as a potent activator of protein kinase C (PKC). PKC plays a role in several signal transduction pathways and can phosphorylate a wide range of target proteins, potentially influencing transcription factors that regulate Glycodelin gene expression. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin, a macrolide antibiotic, is known to modulate immune responses and can also influence signal transduction pathways. While its primary action is to inhibit bacterial protein synthesis, it can affect eukaryotic cells, potentially altering transcriptional regulation of proteins, including Glycodelin. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a GSK-3 inhibitor. By inhibiting GSK-3, lithium chloride can stabilize beta-catenin, thereby possibly enhancing Wnt signaling pathway activity, which is known to be involved in the regulation of a variety of genes, including those related to Glycodelin expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the most abundant catechin in tea and has been shown to modulate several signaling pathways, including those related to inflammation and hormone regulation. This modulation may influence transcriptional activity and can be linked to the regulation of proteins such as Glycodelin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that acts as a tyrosine kinase inhibitor and has been shown to modulate estrogen receptor activity. It can influence signal transduction pathways that regulate cell growth and differentiation, potentially affecting Glycodelin expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound within the isothiocyanate group of organosulfur compounds. It has been shown to affect transcription factor NRF2, which is involved in the response to oxidative stress and may regulate genes associated with Glycodelin production. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a biologically active polyphenolic compound found in turmeric. It can modulate various signaling pathways, including NF-kB, which is a critical regulator of immune response and may influence Glycodelin gene expression. | ||||||