Glut6 inhibitors belong to a specialized category of chemical compounds that have attracted attention in the field of molecular biology and cellular glucose transport research. Glut6, or Glucose transporter 6, is a member of the glucose transporter protein family responsible for facilitating the transport of glucose across cell membranes. The term Glut6 inhibitors refers to a group of molecules meticulously designed to selectively target and modulate the activity of Glut6. These inhibitors serve as invaluable tools in laboratory investigations, enabling researchers to explore the intricate molecular functions and cellular processes associated with Glut6.
Glut6 inhibitors typically function by interfering with the transport function or expression of Glut6, potentially disrupting glucose uptake by cells that rely on this transporter. This interference can lead to alterations in cellular glucose metabolism, impacting various aspects of energy homeostasis and cellular processes that depend on glucose availability. Researchers employ Glut6 inhibitors to gain insights into the physiological roles and molecular interactions of Glut6 within cells, aiming to advance our understanding of the fundamental mechanisms involved in glucose transport, glucose sensing, and the regulation of glucose metabolism. Through the study of Glut6 inhibitors, scientists seek to unravel the complexities of cellular glucose utilization, glucose transport regulation, and the broader field of molecular and cellular biology, contributing to our knowledge of how cells manage glucose as a vital energy source.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, which can decrease the transcription of various genes, including those encoding transporters like GLUT6. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to inhibit the transcription of a wide range of genes, potentially affecting GLUT6 expression indirectly. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin targets RNA polymerase II and inhibits mRNA synthesis which could downregulate GLUT6 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can alter gene expression patterns, possibly affecting GLUT6 transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and affects transcription factor binding, potentially decreasing GLUT6 gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is another DNA methyltransferase inhibitor, potentially altering the epigenetic state of the GLUT6 gene and its expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can elevate lysosomal pH and may disrupt transcriptional regulation, potentially affecting GLUT6 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus inhibits mTOR, a pathway that controls protein synthesis at the translational level, which could indirectly reduce GLUT6 levels. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate has been shown to alter gene expression profiles, which could theoretically reduce GLUT6 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences various signaling pathways and gene expressions, which might affect GLUT6 expression. | ||||||