Glut2 Activators
Glut2 activators comprise a diverse class of chemicals that exert their effects on the glucose transporter 2 (Glut2) protein, a crucial component in cellular glucose transport. These activators can be broadly categorized into direct and indirect modulators of Glut2 function. Direct activators, such as Forskolin, interact directly with Glut2, initiating specific downstream signaling cascades. Forskolin activates the cAMP/PKA pathway, influencing Glut2 expression and function directly. Indirect activators, including Genipin, Quercetin, and AICAR, influence Glut2 activity through various cellular pathways. Genipin, for example, activates AMPK, modulating Glut2 expression and cellular glucose uptake. The intricate cross-talk between energy-sensing pathways and glucose transport exemplifies the indirect activation of Glut2 by Genipin. Similarly, Quercetin modulates the PI3K/Akt pathway, influencing Glut2 expression and cellular glucose uptake, providing a unique avenue for indirectly supporting Glut2 activation.
In summary, Glut2 activators play a pivotal role in regulating cellular glucose uptake processes. The modulation of cellular energy-sensing pathways, such as AMPK and PI3K/Akt, highlights the intricate interplay between these pathways and Glut2-mediated glucose transport, providing a foundation for further exploration of chemical modulators in glucose homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a direct activator of Glut2 that operates through the cAMP/PKA pathway. By activating adenylate cyclase, Forskolin increases intracellular cAMP levels, leading to the activation of protein kinase A (PKA). PKA, in turn, modulates Glut2 expression and function, directly supporting the activation of Glut2 in glucose transport. Forskolin's role in the cAMP/PKA pathway exemplifies its specific impact on Glut2 activity, making it a potent and targeted activator. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin indirectly activates Glut2 by modulating the PI3K/Akt pathway. This flavonoid activates Akt, influencing Glut2 expression and cellular glucose uptake. The specific impact of Quercetin on the PI3K/Akt pathway provides a unique avenue for indirectly supporting Glut2 activation, showcasing its potential as a chemical modulator in glucose transport processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, or Acadesine, indirectly activates Glut2 through AMP-activated protein kinase (AMPK) activation. By mimicking AMP, AICAR activates AMPK, influencing Glut2 expression and glucose transport. This indirect activation of Glut2 highlights the role of AICAR as a chemical modulator of cellular energy-sensing pathways, providing a targeted approach for influencing Glut2 activity in glucose uptake processes. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone indirectly activates Glut2 through peroxisome proliferator-activated receptor gamma (PPARγ) activation. By binding to PPARγ, Troglitazone influences Glut2 expression and function, providing a specific pathway for indirect Glut2 activation. The modulation of PPARγ signaling by Troglitazone illustrates its potential as a chemical modulator in glucose transport, showcasing its impact on Glut2-mediated cellular processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine indirectly activates Glut2 through AMP-activated protein kinase (AMPK) activation. By activating AMPK, Berberine influences Glut2 expression and cellular glucose uptake. This indirect activation of Glut2 highlights the role of Berberine as a chemical modulator of cellular energy-sensing pathways, providing a targeted approach for influencing Glut2 activity in glucose transport processes. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
Zidovudine indirectly activates Glut2 through the PI3K/Akt pathway. By modulating Akt signaling, Zidovudine influences Glut2 expression and cellular glucose uptake. This indirect activation of Glut2 showcases the potential impact of Zidovudine as a chemical modulator in glucose transport processes, providing a specific avenue for influencing Glut2 activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone indirectly activates Glut2 through peroxisome proliferator-activated receptor gamma (PPARγ) activation. By binding to PPARγ, Rosiglitazone influences Glut2 expression and function, providing a specific pathway for indirect Glut2 activation. The modulation of PPARγ signaling by Rosiglitazone illustrates its potential as a chemical modulator in glucose transport, showcasing its impact on Glut2-mediated cellular processes. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin indirectly activates Glut2 through AMP-activated protein kinase (AMPK) activation. By influencing cellular energy status, Metformin activates AMPK, which, in turn, modulates Glut2 expression and function. This indirect activation of Glut2 highlights the role of Metformin as a chemical modulator of cellular energy-sensing pathways, providing a targeted approach for influencing Glut2 activity in glucose transport processes. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin indirectly activates Glut2 by modulating the PI3K/Akt pathway. This flavonoid activates Akt, influencing Glut2 expression and cellular glucose uptake. The specific impact of Luteolin on the PI3K/Akt pathway provides a unique avenue for indirectly supporting Glut2 activation, showcasing its potential as a chemical modulator in glucose transport processes. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662 indirectly activates Glut2 through peroxisome proliferator-activated receptor gamma (PPARγ) activation. By inhibiting PPARγ, GW9662 influences Glut2 expression and function, providing a specific pathway for indirect Glut2 activation. The modulation of PPARγ signaling by GW9662 illustrates its potential as a chemical modulator in glucose transport, showcasing its impact on Glut2-mediated cellular processes. | ||||||