Date published: 2026-5-8

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GlnRS Inhibitors

GlnRS inhibitors belong to a distinctive chemical class that specifically targets the enzyme glutaminyl-tRNA synthetase (GlnRS), a critical component in the protein synthesis machinery of cells. GlnRS is responsible for catalyzing the attachment of glutamine to its cognate transfer RNA (tRNA), a fundamental step in the accurate incorporation of glutamine into nascent polypeptide chains during translation. Inhibitors of GlnRS interfere with this enzymatic process, disrupting the normal progression of protein synthesis. By selectively impeding the function of GlnRS, these inhibitors act as potent modulators of cellular activity, influencing the overall landscape of protein expression within the cell. GlnRS inhibitors often involves small organic compounds that exhibit high affinity and specificity for the active site of the GlnRS enzyme. These inhibitors may function through competitive binding, obstructing the access of glutamine to the enzyme's catalytic pocket. Alternatively, they may operate through non-competitive mechanisms, altering the enzyme's conformation and impairing its ability to catalyze the aminoacylation reaction. The development of GlnRS inhibitors represents a targeted approach to manipulate cellular processes at the molecular level, offering insights into the intricate mechanisms governing protein synthesis.

Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-Albizziin

1483-07-4sc-218627
sc-218627A
sc-218627B
250 mg
1 g
5 g
$143.00
$337.00
$1617.00
(0)

L-Albizziin acts as a potent glnrs, exhibiting unique reactivity as an acid halide. Its structure facilitates nucleophilic attack, leading to the formation of stable intermediates that enhance reaction rates. The compound's ability to engage in specific molecular interactions allows for selective reactivity with various substrates, influencing reaction pathways. Additionally, its physical properties, such as solubility and polarity, contribute to its distinct behavior in chemical environments, making it a versatile reagent in synthetic applications.

Halofuginone

55837-20-2sc-507290
100 mg
$1775.00
(0)

Halofuginone inhibits prolyl-tRNA synthetase, in the same aminoacyl-tRNA synthetase family as GlnRS, and disrupts protein synthesis.

Borrelidin

7184-60-3sc-200379
sc-200379A
100 µg
1 mg
$96.00
$230.00
2
(1)

Borrelidin targets threonyl-tRNA synthetase, an enzyme in the aminoacyl-tRNA synthetase family like GlnRS, affecting protein synthesis.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Anisomycin inhibits protein synthesis by interfering with peptidyl transferase activity, which could affect the functioning of GlnRS.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

Tunicamycin inhibits N-linked glycosylation, a process that could modify GlnRS or proteins in associated pathways.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

Cycloheximide inhibits the elongation phase of protein synthesis, affecting the process that GlnRS is involved in.

Geldanamycin

30562-34-6sc-200617B
sc-200617C
sc-200617
sc-200617A
100 µg
500 µg
1 mg
5 mg
$39.00
$59.00
$104.00
$206.00
8
(1)

Geldanamycin can inhibit the heat shock protein Hsp90, which assists in protein folding and could influence GlnRS function.

Puromycin dihydrochloride

58-58-2sc-108071
sc-108071B
sc-108071C
sc-108071A
25 mg
250 mg
1 g
50 mg
$42.00
$214.00
$832.00
$66.00
394
(16)

Puromycin causes premature chain termination during translation, which affects the process that GlnRS is involved in.

Streptozotocin (U-9889)

18883-66-4sc-200719
sc-200719A
1 g
5 g
$116.00
$530.00
152
(7)

Streptozotocin can inhibit DNA methylation, which could indirectly affect the expression or function of GlnRS.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, a key regulator of protein synthesis, which can indirectly influence GlnRS activity.