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L-Albizziin (CAS 1483-07-4)

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Alternate Names:
H-β-(Ureido)-Ala-OH
Application:
L-Albizziin is Albizziin is a glutamase inhibitor, a glutaminyl-tRNA synthetase inhibitor as well as an intermediate in the synthesis of heterocycles.
CAS Number:
1483-07-4
Molecular Weight:
147.13
Molecular Formula:
C4H9N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Albizziin is notable for its role as a potent inhibitor of glucosamine-6-phosphate synthase, an enzyme pivotal in the biosynthesis of amino sugars. Researchers utilize this compound to study the enzyme′s function and regulation, which is for understanding amino sugar metabolism and its implications in various biological processes. Its ability to selectively inhibit this enzyme makes it useful for probing the metabolic pathways that contribute to cell wall biosynthesis, particularly in fungal organisms. In addition, L-Albizziin is employed in investigations aimed at elucidating the mechanisms of antibiotic resistance that involve the amino sugar pathways, providing insights that could lead to novel strategies to combat resistant microbial species. Its application in research extends to the exploration of chitin production, a component of the fungal cell wall.


L-Albizziin (CAS 1483-07-4) References

  1. Purification and characterisation of a novel cysteine conjugate beta-lyase from the tapeworm Moniezia expansa.  |  Adcock, HJ., et al. 2000. Int J Parasitol. 30: 567-71. PMID: 10779568
  2. Molecular recognition of amino acids by RNA aptamers: the evolution into an L-tyrosine binder of a dopamine-binding RNA motif.  |  Mannironi, C., et al. 2000. RNA. 6: 520-7. PMID: 10786843
  3. Purification and characterisation of a glutaminase from Debaryomyces spp.  |  Durá, MA., et al. 2002. Int J Food Microbiol. 76: 117-26. PMID: 12038568
  4. Glutamine metabolism in skeletal muscles from the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus).  |  Wu, GY., et al. 1991. Biochem J. 274 (Pt 3): 769-74. PMID: 2012604
  5. Biochemical characterization and antitumor study of L-glutaminase from Bacillus cereus MTCC 1305.  |  Singh, P. and Banik, RM. 2013. Appl Biochem Biotechnol. 171: 522-31. PMID: 23873638
  6. Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine.  |  Pinto, JT., et al. 2014. J Biol Chem. 289: 30950-61. PMID: 25231977
  7. Purification and characterization of cysteine conjugate transaminases from rat liver.  |  Tomisawa, H., et al. 1988. Xenobiotica. 18: 1015-28. PMID: 2852419
  8. Purification, characterization and anticancer efficiency of L-glutaminase from Aspergillus flavus.  |  Abu-Tahon, MA. and Isaac, GS. 2020. J Gen Appl Microbiol. 65: 284-292. PMID: 31130583
  9. Identification of a reactive cysteine residue at the glutamine binding site of carbamyl phosphate synthetase.  |  Pinkus, LM. and Meister, A. 1972. J Biol Chem. 247: 6119-27. PMID: 4568602
  10. Action of liver glutamine transaminase and L-amino acid oxidase on several glutamine analogs. Preparation and properties of the 4-S, O, and NH analogs of alpha-ketoglutaramic acid.  |  Cooper, AJ. and Meister, A. 1973. J Biol Chem. 248: 8499-505. PMID: 4797019
  11. Inhibition of homocysteine sulfonamide of glutamate synthase purified from Saccharomyces cerevisiae.  |  Masters, DS. and Meister, A. 1982. J Biol Chem. 257: 8711-5. PMID: 7047525
  12. [Metabolism of L-albizziin in rat liver slices].  |  Fitsner, AB. 1978. Vopr Med Khim. 24: 832-6. PMID: 734988

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Albizziin, 250 mg

sc-218627
250 mg
$143.00

L-Albizziin, 1 g

sc-218627A
1 g
$337.00

L-Albizziin, 5 g

sc-218627B
5 g
$1617.00