GLIS2 Activators
GLIS2, also known as GLI-similar 2, is a transcription factor belonging to the Krüppel-like zinc finger protein family, playing a pivotal role in the transcriptional regulation of genes. It is implicated in a variety of biological processes, including cellular differentiation, maintenance of tissue homeostasis, and embryonic development. The precise mechanisms by which GLIS2 operates involve binding to specific DNA sequences and governing the transcriptional fate of its target genes. It is noteworthy for its association with nephronophthisis, a genetic condition characterized by kidney dysfunction, but its broader biological functions extend to influence the development and function of multiple organ systems. The protein operates within a complex network of cellular signals and regulatory pathways, underlining the sophisticated control of gene expression in human cells.
Understanding the regulation of GLIS2 expression is of scientific interest, as this could uncover fundamental aspects of cell biology and gene regulation. Several chemical compounds have been identified that can potentially serve as activators of GLIS2 expression. For instance, retinoic acid, a metabolite of vitamin A, is known for its ability to activate nuclear receptors that can stimulate the transcription of a wide array of genes, including potentially GLIS2. Moreover, 5-Azacytidine, which inhibits DNA methylation, can lead to the reactivation of gene expression, offering a pathway to induce the expression of GLIS2. Compounds like Trichostatin A and Sodium butyrate, both histone deacetylase inhibitors, are known to cause changes in chromatin structure, thereby facilitating the transcription of certain genes. Forskolin, through the elevation of cAMP, can activate protein kinase A and enhance the transcription of genes that have cAMP response elements in their promoters. These examples illustrate the diversity of biochemical tools that can be used to study the regulation of gene expression, providing insights into the cellular machinery that maintains the intricate balance of protein levels within the human body.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can bind to and activate nuclear receptors, which can initiate the transcription of target genes including GLIS2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A can enhance the acetylation of histones, promoting a more open chromatin state and the potential upregulation of GLIS2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can elevate intracellular cAMP, which may activate protein kinase A and lead to the enhanced transcription of cAMP-responsive genes such as GLIS2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This compound can activate protein kinase C, which may trigger a cascade of events that lead to the upregulation of genes including GLIS2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3beta, potentially leading to the stabilization of beta-catenin and subsequent induction of Wnt target genes, including GLIS2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate's inhibition of histone deacetylases can cause hyperacetylation of histones, which may enhance the transcriptional activation of genes like GLIS2. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
The active metabolite of Cholecalciferol can bind to the vitamin D receptor, which may stimulate the transcription of vitamin D-responsive genes, potentially including GLIS2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol can activate several signal transduction pathways, which might lead to the stimulation of antioxidant response elements and the upregulation of genes like GLIS2. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates AMPK, which may promote the transcriptional activation of genes involved in energy metabolism, potentially including GLIS2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate sirtuins and AMPK, which may promote the upregulation of longevity and stress response genes, potentially encompassing GLIS2. | ||||||