Date published: 2026-5-4

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GLCNE Inhibitors

GLCNE inhibitors, also known as GlcNAc transferase inhibitors, belong to a specific chemical class that exerts its effects by targeting the enzyme glucosamine (GlcNAc) transferase. This enzyme is a crucial player in the process of O-GlcNAcylation, which involves the addition of N-acetylglucosamine (GlcNAc) moieties to serine and threonine residues of various proteins within the cell. This modification process, termed O-GlcNAcylation, is a dynamic and reversible post-translational modification that regulates numerous cellular functions, including signal transduction, transcriptional regulation, protein stability, and cellular stress responses.GLCNE inhibitors are designed to specifically block or modulate the activity of GlcNAc transferase, thereby interfering with the O-GlcNAcylation process. By doing so, these inhibitors can have a profound impact on cellular signaling pathways and regulatory mechanisms, altering the function of key proteins and influencing cellular processes. The inhibition of GlcNAc transferase can lead to alterations in protein-protein interactions, protein localization, and overall cellular homeostasis. As research into GLCNE inhibitors advances, scientists aim to gain a deeper understanding of their mechanisms of action and explore their potential applications in various biological and physiological contexts. Studying the effects of GLCNE inhibitors on cellular processes may shed light on previously unexplored regulatory mechanisms and contribute to the advancement of basic scientific knowledge in the fields of cell biology and biochemistry.

Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

3-O-Methyl-N-acetyl-D-glucosamine

94825-74-8sc-202886A
sc-202886
sc-202886B
1 mg
5 mg
10 mg
$102.00
$245.00
$388.00
2
(1)

3-O-Methyl-N-acetyl-D-glucosamine (CAS 94825-74-8) is a chemical compound known for its inhibitory action on the enzyme GLCNE. By targeting GLCNE, it modulates specific biochemical pathways.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

A potent kinase inhibitor that targets a wide range of kinases. By inhibiting kinase activity, it can prevent phosphorylation events essential for the activation of many signaling pathways, potentially leading to the suppression of target protein functions.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor that blocks the phosphatidylinositol 3-kinase pathway. This action reduces Akt phosphorylation, which can indirectly inhibit proteins involved in cell survival and proliferation, impacting proteins downstream or within this pathway.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

A MEK inhibitor that prevents the activation of the MAPK/ERK pathway. By inhibiting MEK, U0126 reduces ERK phosphorylation, which is crucial for the regulation of various cellular processes, potentially affecting proteins regulated by this pathway.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

A p38 MAPK inhibitor that interferes with the p38 signaling pathway. This inhibition can alter inflammatory response and cell differentiation processes, potentially affecting proteins that are regulated by or interact with the p38 MAPK pathway.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

A specific inhibitor of MEK1/2, blocking the MAPK/ERK pathway. This leads to decreased cell proliferation and differentiation signals, which can indirectly impact proteins associated with this signaling cascade.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

A potent inhibitor of PI3K, affecting various cellular processes including growth, proliferation, and survival by disrupting PI3K/Akt signaling, possibly influencing the function of proteins within this pathway.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor that blocks the mTORC1 pathway, impacting cell growth, proliferation, and survival. This can indirectly affect proteins regulated by or involved in the mTOR signaling pathway.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

An inhibitor of JNK, affecting the JNK signaling pathway involved in apoptosis and cell differentiation. By inhibiting JNK activity, it could influence proteins that are part of or regulated by this pathway.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$94.00
$227.00
30
(1)

A Src family kinase inhibitor that can impede signaling pathways involving Src kinases, affecting processes like cell adhesion, proliferation, and differentiation, potentially impacting related protein functions.