Molecular structure of 3-O-Methyl-N-acetyl-D-glucosamine, CAS Number: 94825-74-8
3-O-Methyl-N-acetyl-D-glucosamine (CAS 94825-74-8)
See product citations (2)
Alternate Names:
3-O-methyl-GlcNAc; 2-(acetylamino)-2-deoxy-3-O-methyl-D-glucose
Application:
3-O-Methyl-N-acetyl-D-glucosamine is an inhibitor of N-acetylglucosamine kinase and N-acetylmannosamine kinase
CAS Number:
94825-74-8
Purity:
≥95%
Molecular Weight:
235.20
Molecular Formula:
C9H17NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-O-Methyl-N-acetyl-D-glucosamine (3-OMe-GlcNAc) is an analog of N-acetyl-D-glucosamine that may act to inhibit GlcNAc kinase (N-acetylglucosamine kinase Ki = 17muM) and GLCNE (N-acetylmannosamine kinase Ki = 80muM). Research has shown that this compound does not inhibit glucokinase activity and is therefore thought to be useful for accurate assay of glucokinase activity in pancreatic islets and liver tissues.
3-O-Methyl-N-acetyl-D-glucosamine (CAS 94825-74-8) References
- Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro. | Zeitler, R., et al. 1992. Eur J Biochem. 204: 1165-8. PMID: 1312935
- Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity. | Radu, RG., et al. 2005. Am J Physiol Endocrinol Metab. 288: E365-71. PMID: 15479952
- Decline in glucokinase activity in the arcuate nucleus of streptozotocin-induced diabetic rats. | Nishio, T., et al. 2006. Biol Pharm Bull. 29: 216-9. PMID: 16462021
- Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain. | Roncero, I., et al. 2009. J Neuroendocrinol. 21: 973-81. PMID: 19807849
- Synthesis of N-acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis. | Wasonga, G., et al. 2013. J Carbohydr Chem. 32: 392-409. PMID: 27099411
- Insecticidal activities of constituents of Litsea cubeba fruit extracts effective against the maize weevil (Coleoptera: Curculionidae). | Zhang, HJ., et al. 2017. J Insect Sci. 17: PMID: 29117378
- Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. | Ricciardiello, F., et al. 2018. Cell Death Dis. 9: 377. PMID: 29515119
- Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway. | Neitzel, LR., et al. 2019. Mech Dev. 156: 20-31. PMID: 30904594
- The Hexosamine Biosynthesis Pathway: Regulation and Function. | Paneque, A., et al. 2023. Genes (Basel). 14: PMID: 37107691
- Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver. | Miwa, I., et al. Enzyme Protein. 48: 135-42. PMID: 8589800
- Potentiation of glucose-induced insulin secretion by fagomine, a pseudo-sugar isolated from mulberry leaves. | Taniguchi, S., et al. 1998. Horm Metab Res. 30: 679-83. PMID: 9918385
Inhibitor of:
GlcNAc kinase, and GLCNE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-O-Methyl-N-acetyl-D-glucosamine, 1 mg | sc-202886A | 1 mg | $102.00 | |||
3-O-Methyl-N-acetyl-D-glucosamine, 5 mg | sc-202886 | 5 mg | $245.00 | |||
3-O-Methyl-N-acetyl-D-glucosamine, 10 mg | sc-202886B | 10 mg | $388.00 |