GDF-1 Inhibitors
Chemical inhibitors of Growth Differentiation Factor 1 (GDF-1) target various components of the signaling pathways that GDF-1 utilizes to exert its biological functions. SB-431542, A-83-01, and SB-505124 specifically inhibit the activin receptor-like kinase (ALK) receptors such as ALK5, which is a critical mediator of the TGF-β superfamily signaling, to which GDF-1 belongs. By inhibiting ALK5, these chemicals prevent the phosphorylation and subsequent activation of Smad2/3 proteins, which are essential for the propagation of GDF-1 signals inside the cell. EW-7197 and LY2109761 also selectively target ALK5, and through this action, they can suppress the Smad-dependent signaling cascades that are necessary for GDF-1's biological activities. Additionally, RepSox and SD-208 are inhibitors of ALK5, further demonstrating the potential for chemical compounds to inhibit GDF-1 function through blockade of its receptor-mediated signaling.
The BMP signaling pathway shares components with the GDF-1 signaling pathway, and as such, inhibitors that act on this pathway can also indirectly affect GDF-1 signaling. LDN-193189, Dorsomorphin, and K02288 inhibit BMP receptors such as ALK2, and by doing so, they can inhibit the signaling activities of GDF-1. DMH1, which is more selective for ALK2, and LDN-212854, which selectively targets the same receptor, can also impede the function of GDF-1 by preventing the phosphorylation and activation of Smad proteins that are shared between the BMP and GDF-1 signaling pathways. By inhibiting these receptors, these chemicals interfere with the intracellular signaling that is necessary for GDF-1 to exert its effects, thereby functionally inhibiting the protein. Through these various mechanisms, each chemical compound can lead to the functional inhibition of GDF-1, affecting its role in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 acts by inhibiting the ALK5 receptor, which is involved in TGF-β signaling. GDF-1 is part of the TGF-β superfamily and signals through similar receptors, hence inhibition of ALK5 by SB-431542 can lead to functional inhibition of GDF-1 signaling. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
A-83-01 is known to inhibit ALK5, ALK4, and ALK7, which are receptors that mediate signaling of TGF-β family proteins including GDF-1. By blocking these receptors, A-83-01 can inhibit GDF-1-mediated signaling. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $321.00 $1350.00 | 2 | |
SB-505124 selectively inhibits ALK5 and ALK7, receptors through which GDF-1 signals. Inhibition of these receptors by SB-505124 can impair the signaling cascade initiated by GDF-1. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
EW-7197 is a selective ALK5 inhibitor, and by inhibiting this kinase, it can interfere with the phosphorylation of Smad proteins, which are downstream effectors in GDF-1 signaling. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $87.00 $270.00 | 9 | |
LY2109761 inhibits TGF-β receptor kinases ALK5 and ALK4. As GDF-1 utilizes these receptors for signaling, LY2109761 can functionally inhibit the action of GDF-1. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 targets ALK2 and ALK3 receptors, which are involved in BMP signaling. As BMP and GDF-1 signaling pathways overlap, inhibition of these receptors can indirectly suppress GDF-1 function. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin inhibits BMP receptors ALK2, ALK3, and ALK6. Since GDF-1 is part of the BMP family, blocking these receptors can inhibit GDF-1 signaling indirectly. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $209.00 $312.00 $620.00 $1026.00 | 2 | |
DMH1 is a selective inhibitor of ALK2, which is a receptor that GDF-1 might utilize indirectly for signaling. Inhibition of ALK2 by DMH1 can lead to functional inhibition of GDF-1. | ||||||
K02288 | 1431985-92-0 | sc-488981 | 5 mg | $330.00 | ||
K02288 is an ALK2 inhibitor. As GDF-1 can signal through receptors that are shared with BMP proteins, inhibition of ALK2 by K02288 can inhibit the function of GDF-1 indirectly. | ||||||
5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1432597-26-6 | sc-476318 | 5 mg | $380.00 | ||
LDN-212854 selectively inhibits BMP receptor kinase ALK2. By inhibiting this kinase, GDF-1 signaling can be indirectly inhibited due to its participation in the BMP signaling pathway. | ||||||