GDF-1 Activators
GDF-1, a critical factor in the TGF-β superfamily, plays a significant role in embryonic development, particularly in heart formation and left-right axis establishment. The functional activity of GDF-1 can be influenced by chemical compounds that modulate the TGF-β/BMP signaling pathways. Compounds such as SB431542, A-83-01, RepSox, and SB505124, which inhibit TGF-β receptors, can create a cellular environment where the role of GDF-1 becomes more pronounced. These inhibitors can lead to compensatory mechanisms in developmental pathways, potentially enhancing the activity of GDF-1 in these critical processes.
Furthermore, BMP pathway modulators like LDN-193189, Dorsomorphin, Noggin, LY364947, and DMH1, which inhibit or antagonize BMP signaling, can indirectly enhance GDF-1's role in embryonic development and cellular differentiation. By altering BMP signaling, these compounds can shift the balance of developmental signaling pathways, potentially increasing the demand for GDF-1 activity in processes like heart development and axis formation. These compounds, through their varied but interconnected actions on TGF-β/BMP signaling pathways, highlight the essential role of GDF-1 in developmental biology, underscoring its importance in the precise regulation of embryogenesis and organ development.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A TGF-β receptor inhibitor, SB431542 can modulate TGF-β signaling, potentially enhancing GDF-1 activity by compensatory mechanisms in developmental pathways. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
A BMP inhibitor, LDN-193189 can alter BMP signaling, which might lead to increased GDF-1 activity in embryonic development processes. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
As an inhibitor of BMP type I receptors, Dorsomorphin could enhance GDF-1 activity by affecting BMP signaling pathways involved in cellular differentiation. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
A selective inhibitor of TGF-β receptors, A-83-01 can modulate TGF-β signaling pathways, potentially enhancing GDF-1's role in developmental and differentiation processes. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
Another TGF-β receptor inhibitor, RepSox can influence TGF-β signaling, potentially enhancing GDF-1 activity in embryogenesis and cellular differentiation. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $321.00 $1350.00 | 2 | |
An inhibitor of TGF-β type I receptor ALK4/5/7, SB505124 can alter TGF-β signaling, potentially enhancing GDF-1's functional activity. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
A TGF-β receptor kinase inhibitor, LY364947 could influence TGF-β/BMP pathways, potentially enhancing GDF-1 activity in developmental processes. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $209.00 $312.00 $620.00 $1026.00 | 2 | |
An inhibitor of BMP type I receptors, DMH1 can modulate BMP signaling, potentially leading to enhanced activity of GDF-1 in developmental signaling. | ||||||