GBP2 Activators
The class of GBP2 activators comprises a variety of chemicals that offer avenues for modulating GBP2 activity. These compounds target various cellular pathways and processes, including cAMP signaling, protein kinase activation, calcium signaling, and immune responses, influencing cellular dynamics and immune-related signaling events. Forskolin, as an activator of adenylyl cyclase, may indirectly activate GBP2 by modulating cAMP signaling, which is linked to interferon-induced responses. PMA, a potent activator of protein kinase C (PKC), may contribute to the indirect activation of GBP2 by influencing cytoskeletal dynamics through PKC activation. Sodium orthovanadate, by inhibiting protein tyrosine phosphatases, may modulate protein tyrosine phosphorylation and interfere with interferon-related signaling, leading to the indirect activation of GBP2. 8-Br-cGMP, as a cGMP analog, can activate cGMP-dependent protein kinase (PKG), modulating interferon pathways and indirectly activating GBP2.
LPS, a bacterial endotoxin, can activate Toll-like receptor 4 (TLR4) signaling, influencing immune-related pathways and contributing to the indirect activation of GBP2. Calyculin A, a protein phosphatase inhibitor, may indirectly activate GBP2 by modulating interferon-related signaling events through the inhibition of protein phosphatases. Rolipram, a PDE4 inhibitor, can increase cAMP levels, influencing interferon pathways and contributing to GBP2 activation. Thapsigargin, by inhibiting the SERCA pump, elevates cytosolic calcium levels, modulating immune responses and indirectly activating GBP2. A23187, a calcium ionophore, facilitates calcium transport across membranes, influencing calcium-dependent signaling events associated with immune responses and contributing to the indirect activation of GBP2. Cyclic AMP, as a second messenger, can activate PKA, modulating interferon pathways and indirectly activating GBP2. Sodium orthovanadate, by inhibiting protein tyrosine phosphatases, may modulate protein tyrosine phosphorylation and interfere with interferon-related signaling, leading to the indirect activation of GBP2. This diverse array of GBP2 activators provides valuable tools for investigating the intricate connections between cellular processes and GBP2 function, enhancing our understanding of the protein's role in cellular dynamics and immune responses.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, leading to increased levels of intracellular cAMP. GBP2 has been associated with interferon-induced responses, and cAMP signaling can modulate interferon pathways. Forskolin's activation of cAMP may contribute to the indirect activation of GBP2 by influencing interferon-related signaling events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). GBP2 has been implicated in cytoskeletal organization, and PKC activation by PMA can influence cytoskeletal dynamics. This may lead to the indirect activation of GBP2 by affecting cellular processes associated with cytoskeletal rearrangement. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, leading to increased protein tyrosine phosphorylation. GBP2 has been linked to interferon-induced responses, and protein tyrosine phosphorylation is involved in interferon signaling. Sodium orthovanadate may contribute to the indirect activation of GBP2 by modulating protein tyrosine phosphorylation and influencing interferon-related pathways. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $102.00 $347.00 | 7 | |
8-Br-cGMP is a cell-permeable analog of cyclic guanosine monophosphate (cGMP) and can activate cGMP-dependent protein kinase (PKG). GBP2 has been associated with interferon-induced responses, and cGMP/PKG signaling can influence interferon pathways. The activation of PKG by 8-Br-cGMP may contribute to the indirect activation of GBP2 by modulating interferon-related signaling events. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
LPS is a bacterial endotoxin that can activate Toll-like receptor 4 (TLR4) signaling. GBP2 has been implicated in immune responses, and TLR4 activation by LPS can modulate immune signaling pathways. This may lead to the indirect activation of GBP2 by influencing immune-related signaling events. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a potent protein phosphatase inhibitor, primarily targeting protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). GBP2 has been linked to interferon-induced responses, and protein phosphatases are involved in interferon signaling. Inhibition of protein phosphatases by Calyculin A may contribute to the indirect activation of GBP2 by modulating interferon-related signaling events. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased levels of intracellular cAMP. GBP2 has been associated with interferon-induced responses, and cAMP signaling can modulate interferon pathways. The inhibition of PDE4 by Rolipram may contribute to the indirect activation of GBP2 by influencing interferon-related signaling events. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, leading to elevated cytosolic calcium levels. GBP2 has been implicated in immune responses, and calcium signaling plays a role in immune cell activation. Thapsigargin may contribute to the indirect activation of GBP2 by modulating calcium-dependent signaling events associated with immune responses. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that facilitates the transport of calcium across cell membranes. GBP2 has been associated with immune responses, and calcium signaling is involved in immune cell activation. A23187 may contribute to the indirect activation of GBP2 by modulating calcium-dependent signaling events associated with immune responses. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Cyclic AMP is a second messenger that can activate protein kinase A (PKA). GBP2 has been linked to interferon-induced responses, and cAMP/PKA signaling can modulate interferon pathways. The activation of PKA by cyclic AMP may contribute to the indirect activation of GBP2 by influencing interferon-related signaling events. | ||||||