GASP-1 Inhibitors
GASP-1 inhibitors belong to a specific chemical class of compounds that target a particular protein called GASP-1, which plays a significant role in various cellular processes. GASP-1, short for GPCR-associated sorting protein 1, is involved in regulating the internalization and recycling of G protein-coupled receptors (GPCRs) within cells. GPCRs are a large family of cell surface receptors that mediate the cellular response to a wide range of signaling molecules, including hormones, neurotransmitters, and sensory stimuli. These receptors are crucial for various physiological processes, making them attractive targets for drug development.
GASP-1 inhibitors are designed to interfere with the interaction between GASP-1 and GPCRs, thereby modulating the sorting and trafficking of these receptors within the cell. By doing so, these inhibitors can potentially influence the downstream signaling cascades initiated by GPCRs. This class of compounds may be valuable tools for researchers studying GPCR biology and may have implications in various areas, including neuroscience, endocrinology, and immunology. Understanding the mechanisms of GASP-1 inhibitors can shed light on the intricate processes of GPCR regulation, which, in turn, may have implications for drug development and our understanding of cellular communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine can inhibit protein kinases that may phosphorylate GASP-1 or its partners, altering their interactions and functions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein can inhibit tyrosine kinases which can modulate GPCR pathways, potentially affecting GASP-1's role in sorting. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 can inhibit Src family kinases, possibly altering GPCR signaling and indirectly affecting GASP-1-mediated sorting. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 can inhibit vacuolar H+ ATPase, which can impact endosomal acidification and potentially disrupt GASP-1 dependent sorting mechanisms. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore can inhibit dynamin, potentially affecting clathrin-mediated endocytosis and GASP-1's function in protein sorting. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 can inhibit MEK, which can impact ERK signaling pathways that may intersect with GASP-1's regulatory roles. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 can inhibit PI3K, which can alter AKT signaling and possibly affect GASP-1 mediated processes. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go 6983 can inhibit Protein Kinase C, which can alter GPCR signaling, possibly impacting GASP-1 functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin can inhibit PI3K, potentially affecting the signaling pathways involving GASP-1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 can inhibit Rho-associated protein kinase, which can affect actin cytoskeleton dynamics and potentially impact GASP-1's role in trafficking. | ||||||