GARNL4 Activators
Items 1 to 10 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor that can inhibit GARNL4 by targeting the kinase activity which is essential for GARNL4 function. Kinase activities are integral to the signaling pathways involving GARNL4, thus inhibition here results in direct loss of GARNL4 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels in cells. Elevated cAMP may enhance GARNL4's role in the regulation of RAP1, a member of the Ras family of GTPases, by promoting the dissociation of RAP1 from GARNL4, thereby facilitating the GTPase activating function of GARNL4 on RAP1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is known to inhibit protein kinase C (PKC). As PKC is upstream of several signaling pathways and may be involved in the activation of the pathways where GARNL4 is critical, its inhibition can result in the subsequent inhibition of GARNL4's role in these pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP, a cell-permeable cAMP analog, mimics the action of endogenous cAMP and can enhance GARNL4's activity by similar mechanisms as forskolin, by indirectly promoting the GTPase activating function of GARNL4 towards RAP1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and regulate proteins involved in the RAP1 signaling pathway. This may indirectly enhance GARNL4 activity by modulating the complex formation or localization of RAP1GAP2 (GARNL4). | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor and since PI3K is involved in the Akt signaling pathway, which may intersect with pathways GARNL4 participates in, its inhibition can decrease the activity of GARNL4 through a reduction in the overall signaling flux through those pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases. Inhibition of competitive kinases could enhance GARNL4's function by reducing negative regulatory phosphorylations that could impact RAP1GAP2's GTPase activating activity towards RAP1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which could inhibit GARNL4 by reducing the signaling through the p38 MAPK pathway if GARNL4 is a downstream effector in this signaling cascade. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, and by inhibiting JNK, it might reduce the activity of downstream proteins that are regulated by JNK signaling, such as GARNL4 if it is part of this signaling network. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, and by blocking PI3K, it can inhibit the activation of pathways that involve GARNL4, resulting in its functional inhibition due to reduced signaling through those pathways. | ||||||