Gar22 Activators
Growth Arrest Specific 2 Like 1, commonly abbreviated as GAS2L1, is a member of the GAS2 family of proteins which are known for their role in the regulation of the cell cycle and cytoskeleton organization. This evolutionarily conserved protein family is characterized by the presence of a Gas2-related domain that interacts with microtubules and is implicated in the coordination of cell proliferation and apoptosis.
GAS2L1 itself is particularly interesting due to its involvement in the stabilization of the microtubule network as well as its role in cytokinesis, the final step of cell division where the cell splits into two daughter cells. The protein is thought to localize to the spindle apparatus during mitosis, and its activity is crucial for the proper alignment and segregation of chromosomes.
The structure of GAS2L1 includes a calponin homology (CH) domain that mediates binding to actin filaments, and a Gas2 domain that is associated with microtubule plus-end tracking (+TIPs). This allows GAS2L1 to act as a cross-linker between actin filaments and microtubules, a function that is essential for maintaining the integrity and dynamics of the cytoskeleton. Furthermore, GAS2L1 may also be involved in cellular processes that require cytoskeletal remodeling, such as cell migration and adhesion.Research has shown that GAS2L1 can be regulated by various cellular signals and may be subject to post-translational modifications that alter its function. Aberrations in the expression or function of GAS2L1 have been suggested to play a role in certain pathological conditions, including cancer, where it may affect tumor cell growth and metastasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can enhance PKA activity, potentially upregulating GAS2L1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression through retinoic acid receptors, which could include transcriptional activation of GAS2L1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases, leading to a more relaxed chromatin state, possibly increasing GAS2L1 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, potentially demethylating the GAS2L1 promoter and enhancing expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which may lead to deacetylation of transcription factors that upregulate GAS2L1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) that might modulate transcription factors involved in GAS2L1 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor, which could increase acetylation and thus expression of GAS2L1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits DNA methyltransferases, potentially leading to hypomethylation and activation of GAS2L1 gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, potentially influencing Wnt signaling and upregulating transcription factors for GAS2L1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which may lead to a compensatory increase in autophagy-related proteins, including GAS2L1. | ||||||