GABP-α Inhibitors
GABP-α inhibitors belong to a specific chemical class of compounds that exert their biological effects by targeting and modulating the activity of the GABP-α transcription factor. GABP-α, or GA-binding protein alpha, is a crucial transcription factor that plays a central role in regulating the expression of various genes involved in cellular processes such as proliferation, differentiation, and metabolism. Inhibitors of GABP-α are designed to interfere with the binding of this transcription factor to its target DNA sequences, thereby disrupting its ability to activate gene expression. This class of compounds represents a promising area of research in the field of molecular biology due to its ability to manipulate gene expression patterns and impact cellular functions.
The mechanism of action of GABP-α inhibitors typically involves the binding of these compounds to specific regions of the GABP-α protein, often at the DNA-binding domain or other critical interaction sites. By binding to GABP-α, these inhibitors can prevent its interaction with DNA and thereby inhibit the transcriptional activation of target genes. This interference with gene expression can have far-reaching consequences on various cellular pathways, making GABP-α inhibitors valuable tools for understanding the regulatory networks that govern cell behavior. Researchers are actively exploring the development and optimization of GABP-α inhibitors to uncover their full potential in deciphering molecular mechanisms within cells and identifying novel applications in the future.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI 2536 is a Plk1 inhibitor that arrests cells in mitosis. As GABP-α is known to control the expression of genes during G2/M transition, the inhibition of Plk1 by BI 2536 would prevent the correct assembly of mitotic spindles, leading to mitotic arrest and indirectly affecting the role of GABP-α in the regulation of mitotic genes. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin is a widely used drug with known effects on cellular metabolism and signaling pathways. It might influence GABP-α expression indirectly through its role in energy balance and metabolism. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that targets both Aurora A and B kinases, key regulators of mitosis. By inhibiting these kinases, ZM447439 can lead to mitotic defects and an aberrant cell cycle, thereby indirectly suppressing the transcriptional activity of GABP-α in the regulation of genes necessary for proper mitotic spindle assembly and chromosome segregation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and it affects various cellular processes. Its potential role in inhibiting GABP-α might be through its effects on cell growth and protein synthesis. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine Sulfate has immunomodulatory effects, and it might influence GABP-α expression indirectly through its role in modulating immune responses and cellular signaling pathways. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
BMS-345541 selectively inhibits the IκB kinase (IKK), which reduces NF-κB signaling. This pathway is involved in the expression of a variety of genes, including those regulated by GABP-α. Therefore, by inhibiting IKK and subsequent NF-κB activation, BMS-345541 can indirectly decrease the transcriptional activity of GABP-α on genes that are co-regulated by NF-κB. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone with known effects on cellular signaling pathways. Its potential effect on GABP-α could be through its role in modulating hormone signaling and cellular growth. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid has anti-inflammatory properties and affects various signaling pathways. Its potential role in inhibiting GABP-α might be through its effects on cellular stress responses and inflammation. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a Chk1 inhibitor that prevents cell cycle arrest in response to DNA damage. GABP-α, which can influence the expression of cell cycle genes, is indirectly inhibited by AZD7762 as it disrupts the DNA damage response, thereby affecting GABP-α-mediated transcriptional activation of genes that are involved in the checkpoint controls. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor and has various biological effects. It might influence GABP-α expression indirectly through its role in chromatin remodeling and gene expression. | ||||||